Image
MIWI RK mutation causes mislocalization of MIWI during spermatogenesis in mice.
| العنوان: | MIWI RK mutation causes mislocalization of MIWI during spermatogenesis in mice. |
|---|---|
| المؤلفون: | Chao Wei, Jiongjie Jing, Xiaoyuan Yan, Jeffrey M. Mann, Ruirong Geng, Huirong Xie, Elena Y. Demireva, Rex A. Hess, Deqiang Ding, Chen Chen |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Developmental Biology, Cancer, Virology, Computational Biology, Physical Sciences not elsewhere classified, germ cell progression, associated pirnas act, tdrd family proteins, spermatogenesis remain elusive, >< sup ><, efficient pirna production, mammalian piwi proteins, div >< p, directing piwi proteins, terminal rg motif, piwi proteins, directing piwi, rg motif, spermatogenesis independent, >, terminal motifs, terminal domains, rg motifs, pirna trimming |
| الوصف: | (A) Testes from indicated mice were immunostained using MIWI and γH2AX antibodies. DNA was stained by DAPI. Different spermatogenic stages were distinguished according to γH2AX staining and DAPI staining. Scale bar, 40 μm. (B) The RK mutation diminishes the recruitment of MIWI to mitochondria in pachytene spermatocytes. Co-immunostaining of MIWI and mitochondrial marker TOMM20 in stage VII–VIII seminiferous tubule from Miwi +/- and Miwi RK/ - testes was performed. DNA was stained by DAPI. Scale bar, 10 μm. Results shown in (A) and (B) are representative of 3 biological replicates. (TIF) |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/MIWI_RK_mutation_causes_mislocalization_of_MIWI_during_spermatogenesis_in_mice_/24555324 |
| DOI: | 10.1371/journal.pgen.1011031.s003 |
| الاتاحة: | https://doi.org/10.1371/journal.pgen.1011031.s003 https://figshare.com/articles/figure/MIWI_RK_mutation_causes_mislocalization_of_MIWI_during_spermatogenesis_in_mice_/24555324 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.E46473C7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pgen.1011031.s003 |
|---|