Academic Journal
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study
| العنوان: | Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study |
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| المؤلفون: | Telomeres Mendelian Randomization Collaboration, Haycock, P. C., Burgess, S., Nounu, A., Zheng, J., Okoli, G. N., Bowden, J., Wade, K. H., Timpson, N. J., Evans, D. M., Willeit, P., Aviv, A., Gaunt, T. R., Hemani, G., Mangino, M., Ellis, H. P., Kurian, K. M., Pooley, K. A, Eeles, R. A., Lee, J. E., Fang, S., Chen, W. V., Law, M. H., Bowdler, L. M., Iles, M. M., Yang, Q., Worrall, B. B., Markus, H. S., Hung, R. J., Amos, C. I., Spurdle, A. B., Thompson, D. J., O'Mara, T. A., Wolpin, B., Amundadottir, L., Stolzenberg-Solomon, R., Trichopoulou, A., Onland-Moret, N. C., Lund, E., Duell, E. J., Canzian, F., Severi, G., Overvad, K., Gunter, M. J., Tumino, R., Svenson, U., van Rij, A., Baas, A. F., Bown, M. J., Samani, Nilesh J., van t'Hof, F. N. G., Tromp, G., Jones, G. T., Kuivaniemi, H., Elmore, J. R., Johansson, M., Mckay, J., Scelo, G., Carreras-Torres, R., Gaborieau, V., Brennan, P., Bracci, P. M., Neale, R. E., Olson, S. H., Gallinger, S., Li, D., Petersen, G. M., Risch, H. A., Klein, A. P., Han, J., Abnet, C. C., Freedman, N. D., Taylor, P. R., Maris, J. M., Aben, K. K., Kiemeney, L. A., Vermeulen, S. H., Wiencke, J. K., Walsh, K. M., Wrensch, M., Rice, T., Turnbull, C., Litchfield, K., Paternoster, L., Standl, M., Abecasis, G. R., SanGiovanni, J. P., Li, Y., Mijatovic, V., Sapkota, Y., Low, S.-K., Zondervan, K. T., Montgomery, G. W., Nyholt, D. R., van Heel, D. A., Hunt, K., Arking, D. E., Ashar, F. N., Sotoodehnia, N., Woo, D., Rosand, J., Comeau, M. E., Brown, W. M., Silverman, E. K., Hokanson, J. E., Cho, M. H., Hui, J., Ferreira, M. A., Thompson, P. J., Morrison, A. C., Felix, J. F., Smith, N. L., Christiano, A. M., Petukhova, L., Betz, R. C., Fan, X., Zhang, X., Zhu, C., Langefeld, C. D., Thompson, S. D., Wang, F., Lin, X., Schwartz, D. A., Fingerlin, T., Rotter, J. I., Cotch, M. F., Jensen, R. A., Munz, M., Dommisch, H., Schaefer, A. S., Han, F., Ollila, H. M., Hillary, R. P., Albagha, O., Ralston, S. H., Zeng, C., Zheng, W., Shu, X.-O., Reis, A., Uebe, S., Hüffmeier, U., Kawamura, Y., Otowa, T., Sasaki, T., Hibberd, M. L., Davila, S., Xie, G., Siminovitch, K., Bei, J.-X., Zeng, Y.-X., Försti, A., Chen, B., Landi, S., Franke, A., Fischer, A., Ellinghaus, D., Flores, C., Noth, I., Ma, S.-F., Foo, J. N., Liu, J., Kim, J.-W., Cox, D. G., Delattre, O., Mirabeau, O., Skibola, C. F., Tang, C. S., Garcia-Barcelo, M., Chang, K.-P., Su, W.-H., Chang, Y.-S., Martin, N. G., Gordon, S., Wade, T. D., Lee, C., Kubo, M., Cha, P.-C., Nakamura, Y., Levy, D., Kimura, M., Hwang, S.-J., Hunt, S., Spector, T., Soranzo, N., Manichaikul, A. W., Barr, R. G., Kahali, B., Speliotes, E., Yerges-Armstrong, L. M., Cheng, C.-Y., Jonas, J. B., Wong, T. Y., Fogh, I., Lin, K., Powell, J. F., Rice, K., Relton, C. L., Martin, R. M., Davey Smith, G. |
| بيانات النشر: | American Medical Association |
| سنة النشر: | 2018 |
| المجموعة: | University of Leicester: Leicester Research Archive (LRA) |
| مصطلحات موضوعية: | Adult, Aged, 80 and over, Cardiovascular Diseases, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Germ-Line Mutation, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Neoplasms, Polymorphism, Single Nucleotide, Risk Assessment, Telomere, Telomere Homeostasis |
| الوصف: | Importance: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. Objective: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. Data Sources: Genomewide association studies (GWAS) published up to January 15, 2015. Study Selection: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. Data Extraction and Synthesis: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. Main Outcomes and Measures: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. Results: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2374-2437 2374-2445 |
| Relation: | https://www.ncbi.nlm.nih.gov/pubmed/28241208; JAMA Oncology, 2017, 3 (5), pp. 636-651; https://jamanetwork.com/journals/jamaoncology/fullarticle/2604820; http://hdl.handle.net/2381/42131; 2604820 |
| DOI: | 10.1001/jamaoncol.2016.5945 |
| الاتاحة: | https://jamanetwork.com/journals/jamaoncology/fullarticle/2604820 http://hdl.handle.net/2381/42131 https://doi.org/10.1001/jamaoncol.2016.5945 |
| Rights: | Copyright © 2017, American Medical Association . Deposited with reference to the publisher’s open access archiving policy. (http://www.rioxx.net/licenses/all-rights-reserved) |
| رقم الانضمام: | edsbas.E45A6285 |
| قاعدة البيانات: | BASE |
| تدمد: | 23742437 23742445 |
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| DOI: | 10.1001/jamaoncol.2016.5945 |