Cross-Linking Enhances Deposition of Human Endothelial Progenitor Cells in the Rat Heart after Intracoronary Transplantation

التفاصيل البيبلوغرافية
العنوان:	Cross-Linking Enhances Deposition of Human Endothelial Progenitor Cells in the Rat Heart after Intracoronary Transplantation
المؤلفون:	Burghoff, Sandra, Ding, Zhaoping, Blaszczyk, Angelika, Wirrwar, Andreas, Buchholz, Doris, Müller, Hans-Wilhelm, Schrader, Jürgen
المصدر:	Cell Transplantation ; volume 19, issue 1, page 113-117 ; ISSN 0963-6897 1555-3892
بيانات النشر:	SAGE Publications
سنة النشر:	2010
الوصف:	Transplantation of human endothelial progenitor cells (hEPCs) may improve vascularization and left ventricular function after myocardial infarction. The scope of this study was to explore, whether cross-linking of EPCs may enhance the deposition of cells in the rat heart after clinical-like, intracoronary transplantation. To this end, 111 In-oxinate-labeled hEPCs were infused by a minimally invasive technique into the coronary arteries of immunosuppressed Wistar rats under control conditions and after ischemia/reperfusion. In a second set of experiments hEPCs were treated with phytohemagglutinin to create small cell clusters prior to transplantation. Continous three-dimensional HiSPECT images for 1 h and after 48 h revealed that cell deposition was significantly higher when hEPCs were cross-linked. Therefore, cross-linking of hEPCs may provide a promising approach to enhance the number of trapped cells also in a clinical setting.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.3727/096368909x474834
DOI:	10.3727/096368909X474834
الاتاحة:	http://dx.doi.org/10.3727/096368909x474834 http://journals.sagepub.com/doi/pdf/10.3727/096368909X474834 http://journals.sagepub.com/doi/full-xml/10.3727/096368909X474834
Rights:	http://journals.sagepub.com/page/policies/text-and-data-mining-license
رقم الانضمام:	edsbas.E447213E
قاعدة البيانات:	BASE

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الوصف
DOI:	10.3727/096368909x474834