Academic Journal
A population of naive-like CD4+ T cells stably polarized to the TH 1 lineage
| العنوان: | A population of naive-like CD4+ T cells stably polarized to the TH 1 lineage |
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| المؤلفون: | Lo, Jonathan W, de Mucha, Maria Vila, Henderson, Stephen, Roberts, Luke B, Constable, Laura E, Garrido-Mesa, Natividad, Hertweck, Arnulf, Stolarczyk, Emilie, Houlder, Emma L, Jackson, Ian, MacDonald, Andrew S, Powell, Nick, Neves, Joana F, Howard, Jane K, Jenner, Richard G, Lord, Graham M |
| المصدر: | Lo , J W , de Mucha , M V , Henderson , S , Roberts , L B , Constable , L E , Garrido-Mesa , N , Hertweck , A , Stolarczyk , E , Houlder , E L , Jackson , I , MacDonald , A S , Powell , N , Neves , J F , Howard , J K , Jenner , R G & Lord , G M 2022 , ' A population of naive-like CD4+ T cells stably polarized to the TH 1 lineage ' , European journal of immunology . https://doi.org/10.1002/eji.202149228 |
| سنة النشر: | 2022 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| الوصف: | T-bet is the lineage-specifying transcription factor for CD4+ T helper type 1 (TH 1) cells. T-bet has also been found in other CD4+ T cell subsets, including TH 17 cells and Treg, where it modulates their functional characteristics. However, we lack information on when and where T-bet is expressed during T cell differentiation and how this impacts T cell differentiation and function. To address this, we traced the ontogeny of T-bet-expressing cells using a fluorescent fate-mapping mouse line. We demonstrate that T-bet is expressed in a subset of CD4+ T cells that have naïve cell surface markers and a naïve cell transcriptional profile and that this novel cell population is phenotypically and functionally distinct from previously described populations of naïve and memory CD4+ T cells. Naïve-like T-bet-experienced cells are polarised to the TH 1 lineage, predisposed to produce IFNγ upon cell activation, and resist repolarisation to other lineages in vitro and in vivo. These results demonstrate that lineage-specifying factors can polarise T cells in the absence of canonical markers of T cell activation and that this has an impact on the subsequent T helper response. This article is protected by copyright. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://research.manchester.ac.uk/en/publications/61f4d5e4-cafa-473c-b549-90da949b05d1 |
| DOI: | 10.1002/eji.202149228 |
| الاتاحة: | https://research.manchester.ac.uk/en/publications/61f4d5e4-cafa-473c-b549-90da949b05d1 https://doi.org/10.1002/eji.202149228 https://pure.manchester.ac.uk/ws/files/211510093/Eur_J_Immunol_2022_Lo_A_population_of_naive_like_CD4_T_cells_stably_polarized_to_the_TH1_lineage.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E440142B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/eji.202149228 |
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