Academic Journal
Stenosis Risk Score for Predicting Outcome in Patients With Asymptomatic Aortic Subscriptions: Information about subscribing to Circulation is online at by EMMANUELE KOUVOUSSIS on Risk Score for Predicting Outcome in Patients With Asymptomatic Aortic Sten
| العنوان: | Stenosis Risk Score for Predicting Outcome in Patients With Asymptomatic Aortic Subscriptions: Information about subscribing to Circulation is online at by EMMANUELE KOUVOUSSIS on Risk Score for Predicting Outcome in Patients With Asymptomatic Aortic Sten |
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| المؤلفون: | Luc Piérard, Pascal Guéret, Jean-Luc Monin, Patrizio Lancellotti, Mehran Monchi, Pascal Lim, Emmanuel Weiss, MD Jean-Luc Monin, PhD, MD, MD Luc Piérard |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.cardiognosis.com/resources/Circulation%202009%20Asymptomatic%20risk%20score.pdf. |
| سنة النشر: | 2009 |
| المجموعة: | CiteSeerX |
| الوصف: | Background-The management of patients with asymptomatic severe aortic stenosis remains controversial. We sought to develop a continuous risk score for predicting the midterm development of symptoms or adverse events in this setting. Methods and Results-We prospectively followed 107 patients with asymptomatic aortic stenosis (aged 72 years [63 to 77]; 35 women; aortic-jet velocity, 4.1 m/s [3.5 to 4.4]) at a single center in France. Predefined end points for assessing outcome were the occurrence within 24 months of death or aortic valve replacement necessitated by symptoms or by a positive exercise test. Variables independently associated with outcome were used to build a score that was validated in an independent cohort of 107 patients from Belgium. Independent predictors of outcome were female sex, peak aortic-jet velocity, and B-type natriuretic peptide at baseline. Accordingly, the score could be calculated as follows: Scoreϭ[peak velocity (m/s)ϫ2]ϩ(natural logarithm of B-type natriuretic peptideϫ1.5)ϩ1.5 (if female sex). Event-free survival after 20 months was 80% for patients within the first score quartile compared with only 7% for the fourth quartile. Areas under the receiver operating characteristic curve for the score were 0.90 and 0.89 in the development and validation cohorts, respectively. Conclusions-If further validation is achieved, this score may be useful to predict outcome in individual patients with asymptomatic aortic stenosis to select those who might benefit from early surgery. (Circulation. 2009;120:69-75.) |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1045.8584; http://www.cardiognosis.com/resources/Circulation%202009%20Asymptomatic%20risk%20score.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1045.8584 http://www.cardiognosis.com/resources/Circulation%202009%20Asymptomatic%20risk%20score.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.E423937A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |