Academic Journal
B-57 * The Temporal Onset of Cognitive Fatigue in Multiple Sclerosis
| العنوان: | B-57 * The Temporal Onset of Cognitive Fatigue in Multiple Sclerosis |
|---|---|
| المؤلفون: | Sandry, J, Wylie, G, DeLuca, J, Genova, H |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2014 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Poster Session B: Thursday, November 13, 6:30 pm - 8:00 pm |
| الوصف: | Objective: The present experiment was designed to better understand cognitive fatigue (CF) in Multiple Sclerosis (MS) by testing a number of competing hypotheses against each other. The hypotheses were: 1) CF is a result of Cognitive Load, 2) CF is a result of Cognitive Domain, or 3) CF is a function of Temporal Onset. An Interactive CF Hypotheses was also possible, whereby CF may result from an interaction between the different factors. Method: 56 patients with MS and 23 Healthy Controls participated. Experimental manipulation included Cognitive Domain (Processing Speed vs Working Memory), Cognitive Load (High vs Low), and Block (Time/Run 1, 2, 3, 4). Domain and Load were counterbalanced and manipulated within participants. Subjective CF was measured using the Visual Analogue Scale at baseline and after each block. Results: Data were analyzed using a 2 (Group: MS vs Healthy Controls) x 2 (Cognitive Domain) x 2 (Cognitive Load) x 4 (Run) Mixed ANOVA. Subjective CF was higher for the Processing Speed task ( p < .001), increased across Runs ( p < .001), and was higher in the MS group ( p = .01). The Run by Group interaction ( p = .02) demonstrates higher subjective CF for the MS group across time. Subjective CF was not correlated with behavior (all p 's = n.s). Conclusion(s): CF was higher for both groups in the processing speed task. Irrespective of Cognitive Load, CF increased as a function of time on task and this was magnified for the MS group. CF was independent of behavior. These data support the hypothesis that CF occurs in MS as a function of Temporal Onset. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://acn.oxfordjournals.org/cgi/content/short/29/6/558-a; http://dx.doi.org/10.1093/arclin/acu038.145 |
| DOI: | 10.1093/arclin/acu038.145 |
| الاتاحة: | http://acn.oxfordjournals.org/cgi/content/short/29/6/558-a https://doi.org/10.1093/arclin/acu038.145 |
| Rights: | Copyright (C) 2014, National Academy of Neuropsychology |
| رقم الانضمام: | edsbas.E419BEE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/arclin/acu038.145 |
|---|