التفاصيل البيبلوغرافية
| العنوان: |
Molecular ecology of cryptococcus neoformans in the Maltese Islands ; Trends in pathology in Malta : papers presented at the Third Maltese Medical School Conference 30 November - 2 December 1995 |
| المؤلفون: |
Todaro Luck, F., Barbara, C., Criseo, G., Pernice, I., Gallo, M., Lo Passo, C. |
| بيانات النشر: |
Department of Pathology, University of Malta |
| سنة النشر: |
1995 |
| المجموعة: |
University of Malta: OAR@UM / L-Università ta' Malta |
| مصطلحات موضوعية: |
Cryptococcus neoformans, AIDS (Disease)-- Complications, AIDS (Disease) -- Patients, Torulosis -- Epidemiology |
| الوصف: |
Cryptococcosis is the most life-threatening deep seated fungal infection in AIDS patients. In immunocompetent hosts cryptococcosis is rare. However its effects are devastating, in both immunocompetent and immunosuppressed patients resulting in death or permanent brain damage, unless cases are diagnosed and treated at an early stage. In Aids a growing problem in the management of secondary diseases is the recurrence of cryptococcosis due to the reactivation of latent strain of c. neoformans probably from prostatic foci. Many questions related to the ecology and epidemiology of Cryptococcus neoformans, the aetiological agents of cryptococcosis, are still unanswered. This extremely versatile fungus is represented by two varieties and five serotypes with different geographical distributions and different epidemiological significance. C. neoformans variety neoformans serotype A has a world wide distribution and it is prevalent in AIDS patients. The serotype D of the same variety has been isolated in Italy, Denmark and France from clinical samples of AIDS patients. Extreme genetic variability among both serotype A and D has been demonstrated by molecular typing techniques. The variety gatti has been isolated in Africa where it is prevalent, in western Australia and in California, leading to the theory that the distribution of Cryptococcus varieties are related to regional climatic conditions. The isolation of both environmental and clinical strains is correlated for variety gatti with the presence of Eucalyptus tree which is the reservoir for this fungus variety (Ellis and Pfeiffer 1990). Beside a different geographical distribution the two varieties possess a different degree of pathogenicity and a different sensitivity to antifungal therapy. In fact the variety gatti is predominantly a pathogen, the variety neoformans is considered opportunistic. However the opportunistic nature of neoformans variety is still being queried. Information about epidemiology and ecology of C. neoformans is lacking in the Mediterranean ... |
| نوع الوثيقة: |
book part |
| اللغة: |
English |
| Relation: |
Todaro Luck, F., et al., (1995). Molecular ecology of cryptococcus neoformans in the Maltese Islands. In M. N. Cauchi (Ed.) Trends in pathology in Malta: papers presented at the Third Maltese Medical School Conference 30 November-2 December 1995 (pp. 33-39). Malta : Department of Pathology, University of Malta.; https://www.um.edu.mt/library/oar/handle/123456789/105853 |
| الاتاحة: |
https://www.um.edu.mt/library/oar/handle/123456789/105853 |
| Rights: |
info:eu-repo/semantics/openAccess ; The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. |
| رقم الانضمام: |
edsbas.E4104E25 |
| قاعدة البيانات: |
BASE |