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小剂量东莨菪碱透皮治疗增加急性心肌梗死患者心脏迷走神经张力 ; Low dose transdermal scopolamine increases cardiac vagal tone in patients afte r acute myocardial infarction

التفاصيل البيبلوغرافية
العنوان: 小剂量东莨菪碱透皮治疗增加急性心肌梗死患者心脏迷走神经张力 ; Low dose transdermal scopolamine increases cardiac vagal tone in patients afte r acute myocardial infarction
المؤلفون: 王留义, 王丽霞, 张永珍, 张炳勇, 陈明哲
المساهمون: 河南省人民医院心内科,郑州,450003, 北京大学第三医院心内科,北京,100083
المصدر: 万方 ; http://d.g.wanfangdata.com.cn/Periodical_zhcmj200205028.aspx
بيانات النشر: Chinese Medical Journal
سنة النشر: 2002
المجموعة: Peking University Institutional Repository (PKU IR) / 北京大学机构知识库
مصطلحات موضوعية: 东莨菪碱, 急性心肌梗死, 迷走神经张力, 心率变异性, 压力反射敏感性, scopolamine, acute myocardial infarction, parasympathetic tone, heart rate variability, baroref lex sensitivity
الوصف: 目的研究心肌梗死急性期经皮给予小剂量东莨菪碱能否增加心脏迷走神经的张力.方法 30例首次急性心肌梗死(AMI)患者,窦性心律,未用任何影响窦房结的药物,随机分为东莨菪碱组和安慰剂组,双盲法给药.治疗前后用数字化24小时Holter记录测定心率变异性时域参数.用苯肾上腺素法测定压力反射敏感性.结果治疗前心率变异性参数和压力反射敏感性在两组间无明显差异.经皮东莨菪碱治疗明显增加心率变异的时域参数[RR间期标准差均值(SDNN),RR间期均值标准差(SDANN)和相邻RR间期差值的均方根(rMSSD)]和频域参数[总功率谱(TP,0-0.40 Hz)、低频(LF,0.40-0.15 Hz)和高频(HF, 0.15-0.40 Hz)]及压力反射敏感性.结论心肌梗死急性期应用小剂量东莨菪碱透皮治疗可显著增加心脏迷走神经张力,改善自主神经失衡. ; Objective To investigate whether transdermal scopolamine increased cardiac vagal activity in patients during the acute phase of myocardial infarction.Methods 30 patients with a first acute myocardial infarction and preserved sinus rhythm who were on no drug that could influence the sinus node were randomly assigned t o either treatment group or placebo group. Measures of heart rate variability ( HRV) in patients given drug or placebo were obtained by digital 24 hour Holter r ecording before and after treatment. Baroreflex sensitivity was performed using the phenylephrine method.Results No significant differences was found in the indices of the time domain and the f requency domain in both groups before treatment. Patients with transdermal scop olamine showed a significant increase in the standard deviation of normal RR int ervals (SDNN), standard deviation of all five min mean normal RR intervals (SDAN N), root mean square of differences of successive normal RR intervals (rMSSD), t otal power (TP, 0.00-0.40Hz), low frequency peak (LF, 0.04-0.15Hz), high frequency peak (HF, 0.15-0.40Hz), and Baroreflex sensitivity after treatmen t (P<0.05-0.01). These indices did not change in patients given placebo. Conclusion Low doses of transdermal scopolamine safely increase cardiac parasympathetic act ivity and improve autonomic indices in patients with acute myocardial infarction . ; SCI(E) ; 0 ; 5 ; 770-772 ; 115
نوع الوثيقة: journal/newspaper
اللغة: Chinese
تدمد: 0366-6999
Relation: 中华医学杂志(英文版).2002,115,(5),770-772.; 1115232; http://hdl.handle.net/20.500.11897/264726
DOI: 10.3760/j.issn:0366-6999.2002.05.028
الاتاحة: https://hdl.handle.net/20.500.11897/264726
https://doi.org/10.3760/j.issn:0366-6999.2002.05.028
رقم الانضمام: edsbas.E4101033
قاعدة البيانات: BASE
الوصف
تدمد:03666999
DOI:10.3760/j.issn:0366-6999.2002.05.028