Academic Journal
Poorly differentiated and anaplastic thyroid cancer: Insights into genomics, microenvironment and new drugs
| العنوان: | Poorly differentiated and anaplastic thyroid cancer: Insights into genomics, microenvironment and new drugs |
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| المؤلفون: | Prete A., Matrone A., Gambale C., Torregrossa L., Minaldi E., Romei C., Ciampi R., Molinaro E., Elisei R. |
| المساهمون: | Prete, A., Matrone, A., Gambale, C., Torregrossa, L., Minaldi, E., Romei, C., Ciampi, R., Molinaro, E., Elisei, R. |
| سنة النشر: | 2021 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Anaplastic thyroid cancer, Genetic landscape, Genetically guided therapy, Poorly thyroid cancer, Tumor microenvironment |
| الوصف: | PDTC and ATC present median overall survival of 6 years and 6 months, respectively. In spite of their rarity, patients with PDTC and ATC represent a significant clinical problem, because of their poor survival and the substantial inefficacy of classical therapies. We reviewed the newest findings about genetic features of PDTC and ATC, from mutations occurring in DNA to alterations in RNA. Therefore, we describe their tumor microenvironments (both immune and not-immune) and the interactions between tumor and neighboring cells. Finally, we recapitulate how this upcoming evidence are changing the treatment of PDTC and ATC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34206867; info:eu-repo/semantics/altIdentifier/wos/WOS:000671082000001; volume:13; issue:13; firstpage:3200; numberofpages:18; journal:CANCERS; https://hdl.handle.net/11568/1122588; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85108607490; https://www.mdpi.com/2072-6694/13/13/3200 |
| DOI: | 10.3390/cancers13133200 |
| الاتاحة: | https://hdl.handle.net/11568/1122588 https://doi.org/10.3390/cancers13133200 https://www.mdpi.com/2072-6694/13/13/3200 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E40ABE17 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers13133200 |
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