التفاصيل البيبلوغرافية
| العنوان: |
Potential for Gut Peptide-Based Therapy in Postprandial Hypotension |
| المؤلفون: |
Malcolm J. Borg, Cong Xie, Christopher K. Rayner, Michael Horowitz, Karen L. Jones, Tongzhi Wu |
| المصدر: |
Nutrients; Volume 13; Issue 8; Pages: 2826 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
postprandial hypotension, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, somatostatin, diabetes mellitus, autonomic failure |
| جغرافية الموضوع: |
agris |
| الوصف: |
Postprandial hypotension (PPH) is an important and under-recognised disorder resulting from inadequate compensatory cardiovascular responses to meal-induced splanchnic blood pooling. Current approaches to management are suboptimal. Recent studies have established that the cardiovascular response to a meal is modulated profoundly by gastrointestinal factors, including the type and caloric content of ingested meals, rate of gastric emptying, and small intestinal transit and absorption of nutrients. The small intestine represents the major site of nutrient-gut interactions and associated neurohormonal responses, including secretion of glucagon-like peptide-1, glucose-dependent insulinotropic peptide and somatostatin, which exert pleotropic actions relevant to the postprandial haemodynamic profile. This review summarises knowledge relating to the role of these gut peptides in the cardiovascular response to a meal and their potential application to the management of PPH. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Nutrition and Diabetes; https://dx.doi.org/10.3390/nu13082826 |
| DOI: |
10.3390/nu13082826 |
| الاتاحة: |
https://doi.org/10.3390/nu13082826 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.E400EE43 |
| قاعدة البيانات: |
BASE |