التفاصيل البيبلوغرافية
| العنوان: |
Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment |
| المؤلفون: |
Burgos-Robles, Anthony Noel, Kimchi, Eyal Yaacov, Izadmehr, Ehsan, Porzenheim, Mary Jane, Ramos-Guasp, William A, Nieh, Edward H, Felix-Ortiz, Ada, Namburi, Praneeth, Leppla, Christopher Albert, Presbrey, Kara N., Anandalingam, Kavitha, Pagan-Rivera, Pablo A, Anahtar, Melodi N., Beyeler, Anna, Tye, Kay M |
| المساهمون: |
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Burgos-Robles, Anthony Noel, Kimchi, Eyal Yaacov, Izadmehr, Ehsan, Porzenheim, Mary Jane, Ramos-Guasp, William A, Nieh, Edward H, Felix-Ortiz, Ada, Namburi, Praneeth, Leppla, Christopher Albert, Presbrey, Kara N., Anandalingam, Kavitha, Pagan-Rivera, Pablo A, Anahtar, Melodi N., Beyeler, Anna, Tye, Kay M |
| المصدر: |
PMC |
| بيانات النشر: |
Nature Publishing Group |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
psy, scipo |
| الوصف: |
Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses, but how information flows between these reciprocally connected structures to coordinate behavior is unknown. We recorded neuronal activity from the BLA and PL while rats performed a task wherein competing shock- and sucrose-predictive cues were simultaneously presented. The correlated firing primarily displayed a BLA→PL directionality during the shock-associated cue. Furthermore, BLA neurons optogenetically identified as projecting to PL more accurately predicted behavioral responses during competition than unidentified BLA neurons. Finally photostimulation of the BLA→PL projection increased freezing, whereas both chemogenetic and optogenetic inhibition reduced freezing. Therefore, the BLA→PL circuit is critical in governing the selection of behavioral responses in the face of competing signals. ; National Institutes of Health (U.S.) (Award 1R25-MH092912-01) ; National Institute of Mental Health (U.S.) (Grant R01- MH102441-01) ; National Institutes of Health (U.S.) (Award DP2- DK-102256-01) |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
http://hdl.handle.net/1721.1/112705 |
| الاتاحة: |
http://hdl.handle.net/1721.1/112705 |
| Rights: |
undefined |
| رقم الانضمام: |
edsbas.E3A4270 |
| قاعدة البيانات: |
BASE |