Academic Journal
Adenosine and inflammation: Here, there and everywhere
| العنوان: | Adenosine and inflammation: Here, there and everywhere |
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| المؤلفون: | Pasquini S., Contri C., Borea P. A., Vincenzi F., Varani K. |
| المساهمون: | Pasquini, S., Contri, C., Borea, P. A., Vincenzi, F., Varani, K. |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi di Ferrara: CINECA IRIS |
| مصطلحات موضوعية: | Adenosine, Adenosine receptor, Chronic inflammatory disease, Immune system, Inflammation |
| الوصف: | Adenosine is a ubiquitous endogenous modulator with the main function of maintaining cellular and tissue homeostasis in pathological and stress conditions. It exerts its effect through the interaction with four G protein-coupled receptor (GPCR) subtypes referred as A1, A2A, A2B, and A3 adenosine receptors (ARs), each of which has a unique pharmacological profile and tissue distribution. Adenosine is a potent modulator of inflammation, and for this reason the adenosinergic system represents an excellent pharmacological target for the myriad of diseases in which inflammation represents a cause, a pathogenetic mechanism, a consequence, a manifestation, or a protective factor. The omnipresence of ARs in every cell of the immune system as well as in almost all cells in the body represents both an opportunity and an obstacle to the clinical use of AR ligands. This review offers an overview of the cardinal role of adenosine in the modulation of inflammation, showing how the stimulation or blocking of its receptors or agents capable of regulating its extracellular concentration can represent promising therapeutic strategies for the treatment of chronic inflammatory pathologies, neurodegenerative diseases, and cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34299305; info:eu-repo/semantics/altIdentifier/wos/WOS:000676431100001; volume:22; issue:14; firstpage:7685-1; lastpage:7685-24; numberofpages:24; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11392/2473719; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85110393885; https://www.mdpi.com/1422-0067/22/14/7685/pdf; https://www.mdpi.com/1422-0067/22/14/7685 |
| DOI: | 10.3390/ijms22147685 |
| الاتاحة: | http://hdl.handle.net/11392/2473719 https://doi.org/10.3390/ijms22147685 https://www.mdpi.com/1422-0067/22/14/7685/pdf https://www.mdpi.com/1422-0067/22/14/7685 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E381BBA7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms22147685 |
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