Academic Journal
Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy
| العنوان: | Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy |
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| المؤلفون: | Plou, Javier, Molina Martínez, Beatriz, García Astrain, Clara, Langer, Judith, García, Isabel, Ercilla Eguiarte, Amaia, Perumal, Govindaraj, Carracedo Pérez, Arkaitz, Liz Marzán, Luis Manuel |
| المساهمون: | European Commission |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2021 |
| المجموعة: | ADDI: Repositorio Institucional de la Universidad del País Vasco / Euskal Herriko Unibertsitatea (UPV/EHU - Basque Country University) |
| مصطلحات موضوعية: | surface-enhanced Raman spectroscopy, SERS, nanocomposite scaffold, 3D cell culture, drug diffusion |
| الوصف: | [EN]Monitoring dynamic processes in complex cellular environments requires the integration of uniformly distributed detectors within such three-dimensional (3D) networks, to an extent that the sensor could provide real-time information on nearby perturbations in a non-invasive manner. In this context, the development of 3D-printed structures that can function as both sensors and cell culture platforms emerges as a promising strategy, not only for mimicking a specific cell niche but also toward identifying its characteristic physicochemical conditions, such as concentration gradients. We present herein a 3D cancer model that incorporates a hydrogel-based scaffold containing gold nanorods. In addition to sustaining cell growth, the printed nanocomposite inks display the ability to uncover drug diffusion profiles by surface-enhanced Raman scattering, with high spatiotemporal resolution. We additionally demonstrate that the acquired information could pave the way to designing novel strategies for drug discovery in cancer therapy, through correlation of drug diffusion with cell death. ; J.P. acknowledges an FPU fellowship from the Spanish Ministry of Science, Innovation and Universities. L.M.L.-M. acknowledges funding from the European Research Council (Grants ERC AdG 787510, 4DbioSERS) and the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency (Grant MDM-2017-0720). A.C. was funded by MICINN (Grant PID2019-108787RB-I00 (FEDER/EU)) and the European Research Council (ERC Consolidator Grant 819242). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1530-6992 |
| Relation: | info:eu-repo/grantAgreement/EC/H2020/787510; info:eu-repo/grantAgreement/EC/H2020/819242; info:eu-repo/grantAgreement/MICINN/PID2019-108787RB-I00; Nano Letters 21(20) : 8785-8793 (2021); http://hdl.handle.net/10810/53804 |
| DOI: | 10.1021/acs.nanolett.1c03070 |
| الاتاحة: | http://hdl.handle.net/10810/53804 https://doi.org/10.1021/acs.nanolett.1c03070 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ; © 2021 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ; Atribución-NoComercial-SinDerivadas 3.0 España |
| رقم الانضمام: | edsbas.E3615379 |
| قاعدة البيانات: | BASE |
| تدمد: | 15306992 |
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| DOI: | 10.1021/acs.nanolett.1c03070 |