Academic Journal
Observational studies on the efficacy of carbamazepine and ascorbyl palmitate in managing trigeminal neuralgia
| العنوان: | Observational studies on the efficacy of carbamazepine and ascorbyl palmitate in managing trigeminal neuralgia |
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| المؤلفون: | Khijmatgar, S, Naik, Z, Carmichael, A, Siddique, S M, Bagewadi, A, Dey Chowdhury, A, Giacomello, M, Parrini, M, Rovati, M, Goker, F, Mortellaro, C, Del Fabbro, M, Chowdhury, C |
| المساهمون: | S. Khijmatgar, Z. Naik, A. Carmichael, S.M. Siddique, A. Bagewadi, A. Dey Chowdhury, M. Giacomello, M. Parrini, M. Rovati, F. Goker, C. Mortellaro, M. Del Fabbro, C. Chowdhury |
| بيانات النشر: | Verduci publisher |
| سنة النشر: | 2022 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Trigeminal nerve, Trigeminal neuralgia, Patient reported outcome measure, Ascorbylpalmitate, Lancinating pain, Settore MED/29 - Chirurgia Maxillofacciale |
| الوصف: | Objective: Ascorbyl palmitate is a fat-soluble ester of vitamin C and is used as an antioxidant food additive. While literature reports that ascorbyl palmitate can prevent exacerbation of pain and improve the quality of life of patients suffering from pain, this is not yet supported by clinical trial data. Our study aimed to investigate the effectiveness of ascorbyl palmitate in managing trigeminal neuralgia. Patients and methods: This study was carried out in a single-centre clinical trial in which subjects suffering from trigeminal neuralgia (N=11) were included. All patients were on carbamazepine when first included and, after washout period, received Ascorbyl palmitate. Eligible patients had the most severe trigeminal neuralgia pain in the oral cavity or pain on touching trigger zones, aged 20 years or older, were capable of proper assessment of the severity of pain and their condition, and had experienced multiple episodes of intraoral pain for at least 3 months with a pain intensity of more than 4 points on the numerical rating scale. The Brief Pain Questionnaire was used to evaluate patient's quality of life. Results: A total of 11 patients were included with a mean age 55.36±10.67 years (7 males, 4 females). Most patients had compression by the superior cerebellar artery and vascular loops upon magnetic resonance examination. The mean numerical rating scale score for carbamazepine after one month was 7.9±0.56 (95% CI 7.49, 8.30). Similarly, for ascorbyl palmitate was 5.5±1.50 (95% CI 4.42, 6.57) (p<0.001). Conclusions: Ascorbyl palmitate can be used as an adjunct intervention in managing trigeminal neuralgia pain. According to the results, ascorbyl palmitate prevents frequent exacerbation of pain and improves patient quality of life. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36591877; info:eu-repo/semantics/altIdentifier/wos/WOS:000922036400011; volume:26; issue:3 Suppl; firstpage:94; lastpage:105; numberofpages:12; journal:EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES; https://hdl.handle.net/2434/951491; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85145344856 |
| DOI: | 10.26355/eurrev_202212_30799 |
| الاتاحة: | https://hdl.handle.net/2434/951491 https://doi.org/10.26355/eurrev_202212_30799 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E32D3FA2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.26355/eurrev_202212_30799 |
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