Academic Journal
Effect of preoperative fever-range whole-body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery
| العنوان: | Effect of preoperative fever-range whole-body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery |
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| المؤلفون: | Sulyok, I., Fleischmann, E., Stift, A., Roth, G., Lebherz-Eichinger, D., Kasper, D., Spittler, A., Kimberger, O. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2012 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Critical Care |
| الوصف: | Background Previous studies have demonstrated beneficial immunological effects of fever-range whole-body hyperthermia (FR-WBH) as an adjunct to non-surgical cancer therapy. We conducted a study of preoperative FR-WBH in patients undergoing colorectal cancer surgery to evaluate perioperative, hyperthermia-induced immunomodulation. Methods The trial was conducted as a subject-blinded, controlled, randomized study. Subjects in the FR-WBH group ( n =9) were treated with FR-WBH before operation under propofol sedation; the target core temperature was 39 (0.5)°C with 1 h warming and 2 h plateau phase. Subjects in the control group ( n =9) were treated with propofol sedation only. Blood samples were acquired before and after treatment, after operation, and 24, 48 h, and 5 days after the end of surgery. The following parameters were measured: lipopolysaccharide (LPS)-induced tumour necrosis factor (TNF)-α, procalcitonin (PCT), interleukin (IL)-6/10, heat shock proteins (HSPs) 60, 70, and 90, human leucocyte antigen-DR (HLA-DR), and LPS-binding protein (LBP). Results HSPs were increased in the FR-WBH group after treatment [HSP60, 48 h postop: 143 (41)% vs 89 (42)%, P =0.04; HSP90, postop: 111 (33)% vs 64 (31)%, P =0.04; HSP70: P =0.40; FR-WBH vs control, P -values for area under the level/time curve]. TNF-α levels were elevated after surgery in the control group and remained near baseline in the FR-WBH group [24 h postop: 73 (68)% vs 151 (72)%, P =0.04]. PCT increased in both groups 24 h after surgery; in the control group, this increase was significantly higher ( P =0.02). There were no significant differences for IL, HLA-DR, or LBP. Conclusions The immune system to react to surgical stress, as measured by a panel of laboratory indicators, might be improved by preoperative FR-WBH. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://bja.oxfordjournals.org/cgi/content/short/109/5/754; http://dx.doi.org/10.1093/bja/aes248 |
| DOI: | 10.1093/bja/aes248 |
| الاتاحة: | http://bja.oxfordjournals.org/cgi/content/short/109/5/754 https://doi.org/10.1093/bja/aes248 |
| Rights: | Copyright (C) 2012, Oxford University Press |
| رقم الانضمام: | edsbas.E2F67330 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/bja/aes248 |
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