Academic Journal
Levels of Inflammation Markers Are Associated with the Risk of Recurrence and All-Cause Mortality in Patients with Colorectal Cancer
| العنوان: | Levels of Inflammation Markers Are Associated with the Risk of Recurrence and All-Cause Mortality in Patients with Colorectal Cancer |
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| المؤلفون: | Wesselink, E., Balvers, M.G.J., Kok, D.E., Winkels, R.M., Zutphen, M. van, Schrauwen, R.W., Keulen, E.T.P., Kouwenhoven, E.A., Breukink, S.O., Witkamp, R.F., Wilt, J.H.W. de, Bours, M.J., Weijenberg, M.P., Kampman, E., Duijnhoven, F. J. B. van |
| المصدر: | Cancer Epidemiology, Biomarkers & Prevention, 30, 6, pp. 1089-1099 |
| سنة النشر: | 2021 |
| المجموعة: | Radboud University: DSpace |
| مصطلحات موضوعية: | Radboudumc 14: Tumours of the digestive tract RIHS: Radboud Institute for Health Sciences |
| الوصف: | Item does not contain fulltext ; BACKGROUND: We investigated whether preoperative and postoperative levels of inflammation markers, which have mechanistically been linked to colorectal cancer progression, were associated with recurrence and all-cause mortality in patients with colorectal cancer. METHODS: Data of two prospective cohort studies were used. For the current analysis, patients with stage I to III colorectal cancer were considered. Data on inflammation [IL6, IL8, IL10, TNFα, high-sensitivity C-reactive protein (hsCRP), and a combined inflammatory z-score] were available for 747 patients before surgery and for 614 patients after surgery. The associations between inflammation marker levels and colorectal cancer recurrence and all-cause mortality were examined using multivariable Cox proportional hazard regression models, considering patient characteristics and clinical and lifestyle factors. RESULTS: Higher preoperative and postoperative hsCRP levels were associated with a higher risk of recurrence [HR(per doubling) (95% CI), 1.15 (1.02-1.30) and 1.34 (1.16-1.55)] and all-cause mortality [HR(per doubling) (95% CI) 1.13 (1.01-1.28) and 1.15 (0.98-1.35)]. A doubling in IL8 levels (preoperative levels HR = 1.23; 95% CI, 1.00-1.53 and postoperative levels HR = 1.61; 95% CI, 1.23-2.12) and a higher combined inflammatory z-score (preoperative HR(per doubling) = 1.39; 95% CI, 1.03-1.89 and postoperative HR(per doubling) = 1.56; 95% CI, 1.06-2.28) were associated with a higher risk of all-cause mortality, but not recurrence. No associations between IL6, IL10, and TNFα and recurrence or all-cause mortality were observed. CONCLUSIONS: Preoperative and postoperative levels of specific inflammation markers were associated with recurrence and/or all-cause mortality. IMPACT: The complex role of inflammation in cancer recurrence merits further elucidation by investigating local inflammation at the tumor site. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://repository.ubn.ru.nl/handle/2066/235775; https://doi.org/10.1158/1055-9965.EPI-20-1752 |
| DOI: | 10.1158/1055-9965.EPI-20-1752 |
| الاتاحة: | https://repository.ubn.ru.nl/handle/2066/235775 https://doi.org/10.1158/1055-9965.EPI-20-1752 |
| رقم الانضمام: | edsbas.E2D9FDED |
| قاعدة البيانات: | BASE |
| DOI: | 10.1158/1055-9965.EPI-20-1752 |
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