التفاصيل البيبلوغرافية
| العنوان: |
Additional file 2 of The expressed mutational landscape of microsatellite stable colorectal cancers |
| المؤلفون: |
Anita Sveen (207182), Bjarne Johannessen (4046060), Ina A. Eilertsen (11375144), Bård I. Røsok (11375147), Marie Gulla (11375150), Peter W. Eide (11375153), Jarle Bruun (4230745), Kushtrim Kryeziu (1674526), Leonardo A. Meza-Zepeda (8069903), Ola Myklebost (123307), Bjørn A. Bjørnbeth (11375156), Rolf I. Skotheim (11375159), Arild Nesbakken (207185), Ragnhild A. Lothe (11375162) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Genetics, Molecular Biology, Cancer, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Colorectal cancer, Exome sequencing, RNA sequencing, Allele-specific mutation expression, Mutant allele fraction, Pharmacogenomics, Drug screening, Patient-derived organoids |
| الوصف: |
Additional file 2: Figure S1. TMB and expressed TMB relative to sequencing coverage and tumor purity. Figure S2. Gene-wise mutation frequency among microsatellite stable CRCs. Figure S3. Gene set enrichment analyses of expressed mutations. Figure S4. Validation of mutation expression frequencies in TCGA. Figure S5. Heatmap of expressed mutations per gene and tumor sample. Figure S6. Logistic PCA of the expressed mutation matrix. Figure S7. Genes with frequent non-expressed mutations. Figure S8. Genes with frequent non-expressed mutated alleles. Figure S9. Genes with both expression and silencing of the mutated allele among tumors. Figure S10. Illustration of estimates used to describe relative allelic expression of mutations. Figure S11. RNA and DNA level MAFs in primary MSS CRCs in the in-house series. Figure S12. RNA MAF versus DNA MAF in TCGA. Figure S13. Genes with high relative allelic expression of mutations. Figure S14. RNA MAF versus DNA MAF in in-house series according to mutation/target gene category. Figure S15. Relative allelic mutation expression in TCGA data according to allelic copy number balance. Figure S16. Allele-specific expression of TP53 and KRAS mutations among 241 primary colon cancers in the TCGA validation series. Figure S17. Allele-specific expression of APC mutations in the in-house series of primary CRCs. Figure S18. Allele-specific mutation expression and drug sensitivity in CRC cell lines. Figure S19. Minimal evolutionary changes in mutation expression during metastasis. Figure S20. Comparisons of DNA MAFs among multiple tumor samples from each of 4 patients. Figure S21. Comparisons of RNA MAFs among multiple tumor samples from each of 4 patients. Figure S22. Comparisons of ΔMAF RNA|DNA among multiple tumor samples from each of 4 patients. Figure S23. Comparisons of RNA read counts of mutated alleles among multiple tumor samples from each of 4 patients. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Additional_file_2_of_The_expressed_mutational_landscape_of_microsatellite_stable_colorectal_cancers/16557230 |
| DOI: |
10.6084/m9.figshare.16557230.v1 |
| الاتاحة: |
https://doi.org/10.6084/m9.figshare.16557230.v1 |
| Rights: |
CC BY + CC0 |
| رقم الانضمام: |
edsbas.E29316AB |
| قاعدة البيانات: |
BASE |