التفاصيل البيبلوغرافية
| العنوان: |
Formation and Expansion of Memory B Cells against Coronavirus in Acutely Infected COVID-19 Individuals |
| المؤلفون: |
A. Karim Embong, Phuong Nguyen-Contant, Jiong Wang, Preshetha Kanagaiah, Francisco A. Chaves, Theresa F. Fitzgerald, Qian Zhou, Gabrielle Kosoy, Angela R. Branche, Benjamin L. Miller, Martin S. Zand, Mark Y. Sangster, David J. Topham |
| المصدر: |
Pathogens; Volume 11; Issue 2; Pages: 186 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
SARS-CoV-2, B cells, antibodies, memory |
| جغرافية الموضوع: |
agris |
| الوصف: |
Infection with the β-coronavirus SARS-CoV-2 typically generates strong virus-specific antibody production. Antibody responses against novel features of SARS-CoV-2 proteins require naïve B cell activation, but there is a growing appreciation that conserved regions are recognized by pre-existing memory B cells (MBCs) generated by endemic coronaviruses. The current study investigated the role of pre-existing cross-reactive coronavirus memory in the antibody response to the viral spike (S) and nucleocapsid (N) proteins following SARS-CoV-2 infection. The breadth of reactivity of circulating antibodies, plasmablasts, and MBCs was analyzed. Acutely infected subjects generated strong IgG responses to the S protein, including the novel receptor binding domain, the conserved S2 region, and to the N protein. The response included reactivity to the S of endemic β-coronaviruses and, interestingly, to the N of an endemic α-coronavirus. Both mild and severe infection expanded IgG MBC populations reactive to the S of SARS-CoV-2 and endemic β-coronaviruses. Avidity of S-reactive IgG antibodies and MBCs increased after infection. Overall, findings indicate that the response to the S and N of SARS-CoV-2 involves pre-existing MBC activation and adaptation to novel features of the proteins, along with the potential of imprinting to shape the response to SARS-CoV-2 infection. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Immunological Responses and Immune Defense Mechanisms; https://dx.doi.org/10.3390/pathogens11020186 |
| DOI: |
10.3390/pathogens11020186 |
| الاتاحة: |
https://doi.org/10.3390/pathogens11020186 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.E28D1A7 |
| قاعدة البيانات: |
BASE |