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Toward DNA-Based Recording of Biological Processes

التفاصيل البيبلوغرافية
العنوان: Toward DNA-Based Recording of Biological Processes
المؤلفون: Hyeri Jang, Sung Sun Yim
المصدر: International Journal of Molecular Sciences, Vol 25, Iss 17, p 9233 (2024)
بيانات النشر: MDPI AG
سنة النشر: 2024
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: DNA-based data storage, molecular recording, cellular memory, synthetic biology, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Exploiting the inherent compatibility of DNA-based data storage with living cells, various cellular recording approaches have been developed for recording and retrieving biologically relevant signals in otherwise inaccessible locations, such as inside the body. This review provides an overview of the current state of engineered cellular memory systems, highlighting their design principles, advantages, and limitations. We examine various technologies, including CRISPR-Cas systems, recombinases, retrons, and DNA methylation, that enable these recording systems. Additionally, we discuss potential strategies for improving recording accuracy, scalability, and durability to address current limitations in the field. This emerging modality of biological measurement will be key to gaining novel insights into diverse biological processes and fostering the development of various biotechnological applications, from environmental sensing to disease monitoring and beyond.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/25/17/9233; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/c4f68d63bcd04cf7ab6d7de69e16423a
DOI: 10.3390/ijms25179233
الاتاحة: https://doi.org/10.3390/ijms25179233
https://doaj.org/article/c4f68d63bcd04cf7ab6d7de69e16423a
رقم الانضمام: edsbas.E26FD40F
قاعدة البيانات: BASE
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms25179233