التفاصيل البيبلوغرافية
| العنوان: |
TB disease severity only correlate with alterations in monocyte subtype distribution and functionality during coinfection. |
| المؤلفون: |
Gezahegn Bewket (10219515), Amare Kiflie (2559619), Ebba Abate (309550), Olle Stendahl (179805), Thomas Schön (309566), Robert Blomgran (179794) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Microbiology, Cell Biology, Ecology, Immunology, Infectious Diseases, Virology, Computational Biology, PTB patients, non-classical monocytes, helminth-positive PTB patients, monocyte subsets, TB patients, frequency, helminth infection, PBMC, helminth species, CC, TNF -α, PPD, Mycobacterium tuberculosis infection, flow cytometric analysis, Low-to-intermediate TB disease severity, 74 PTB patients |
| الوصف: |
(A) Analysis of PBMCs without ex vivo incubation. Frequency of classical, intermediate and non-classical monocyte subsets in pulmonary TB patients (PTB) based on their helminth status and disease severity using TBscore to classify patients into the three disease severity classes (SCI, SCII, SCIII). (B) Frequency of TNF-α producing classical, intermediate and non-classical monocytes in unstimulated PBMCs of PTB patients within the different disease severity classes. (C) Similar to (B) but for PBMCs stimulated with PPD for 6h. Data was from PTB patients with SCI (n = 13/13), SCII (9/10), and SCIII (n = 17/9), that were Helm-/Helm+, respectively. Data presented as the mean frequency ± SEM of monocyte subsets within each disease severity class of PTB patients, and the frequency of TNF-α producing monocytes within those. For non-classical monocytes in (A), brackets indicate the analysis when SCI and SCII (SCI-SCII) have been combined. p values were calculated by two-way ANOVA followed by Sidak’s multiple comparison test, and asterisks (*, **) show the main effect of disease severity between the helminth negative and helminth positive group. Additionally, the differences to SCII (or the combined SCI-II) within the group of helminth positive PTB patients are indicated by number sign (#, ##). */#, p < 0.05; **/##, p < 0.01. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/TB_disease_severity_only_correlate_with_alterations_in_monocyte_subtype_distribution_and_functionality_during_coinfection_/14143356 |
| DOI: |
10.1371/journal.pntd.0009194.g006 |
| الاتاحة: |
https://doi.org/10.1371/journal.pntd.0009194.g006 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.E26493F7 |
| قاعدة البيانات: |
BASE |