Academic Journal
Sex difference in 5HT2 receptor in the living human brain.
| العنوان: | Sex difference in 5HT2 receptor in the living human brain. |
|---|---|
| المؤلفون: | Biver, Françoise, Lotstra, Françoise, Monclus, Michel, Wikler, David, Damhaut, Philippe, Mendlewicz, Julien, Goldman, Serge |
| المصدر: | Neuroscience letters, 204 (1-2 |
| سنة النشر: | 1996 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles, Adult, Brain Chemistry -- physiology, Female, Fluorine Radioisotopes -- diagnostic use, Humans, Ketanserin -- analogs & derivatives, Ketanserin -- diagnostic use, Ketanserin -- pharmacokinetics, Male, Middle Aged, Receptors, Serotonin -- metabolism, Sex Characteristics, Tomography, Emission-Computed |
| الوصف: | Serotonergic mechanisms are involved in gender-related behaviors and psychiatric conditions like aggression, eating disorders, depression, impulsivity or suicide. We studied gender differences in the living human brain type-2 serotonin receptor (5HT2r). Twenty-two healthy age-matched men and women were investigated using positron emission tomography and the selective radiotracer, 18F-labeled altanserin. Binding was quantified using a non-linear least-squares minimization procedure. We found significantly higher 5HT2r binding capacity in men than in women, especially in the frontal and cingulate cortices. Distinct liability for men and women to suffer from some psychiatric disorders responding to serotonergic agents may be related to differences in brain serotonin receptors. ; Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| Relation: | uri/info:doi/10.1016/0304-3940(96)12307-7; uri/info:pii/0304-3940(96)12307-7; uri/info:pmid/8929969; uri/info:scp/0029670979; local/VX-004178; https://dipot.ulb.ac.be/dspace/bitstream/2013/56363/4/11c92132-9665-4d98-80f0-e23965555800.txt; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/56363 |
| الاتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/56363 https://dipot.ulb.ac.be/dspace/bitstream/2013/56363/4/11c92132-9665-4d98-80f0-e23965555800.txt |
| رقم الانضمام: | edsbas.E23C621F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |