Academic Journal
A fear memory engram and its plasticity in the hypothalamic oxytocin system
| العنوان: | A fear memory engram and its plasticity in the hypothalamic oxytocin system |
|---|---|
| المؤلفون: | Hasan, M., Althammer, F., da Gouveia , M., Goyon , S., Eliava, M., Lefevre , A., Kerspern , D., Schimmer , J., Raftogianni, A., Wahis , J., Knobloch, S., Tang , Y., Liu , X., Jain, A., Chavant , V., Goumon , Y., Weislogel , J., Hurlemann , R., Herpertz , S., Pitzer , C., Darbon , P., Dogbevia, G., Bertocchi, I., Larkum, M., Sprengel, R., Bading , H., Charlet , A., Grinevich, V. |
| المصدر: | Neuron |
| سنة النشر: | 2019 |
| المجموعة: | Max Planck Society: MPG.PuRe |
| الوصف: | Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identified and permanently tagged a small subpopulation of OT cells, which, by optogenetic stimulation, strongly attenuated contextual fear-induced freezing, and pharmacogenetic silencing of tagged OT neurons impaired context-specific fear extinction, demonstrating that the tagged OT neurons are sufficient and necessary, respectively, to control contextual fear. Intriguingly, OT cell terminals of fear-experienced rats displayed enhanced glutamate release in the amygdala. Furthermore, rats exposed to another round of fear conditioning displayed 5-fold more activated magnocellular OT neurons in a novel environment than a familiar one, possibly for a generalized fear response. Thus, our results provide first evidence that hypothalamic OT neurons represent a fear memory engram. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://hdl.handle.net/21.11116/0000-0003-A0EC-E; http://hdl.handle.net/21.11116/0000-0005-63DC-4 |
| الاتاحة: | http://hdl.handle.net/21.11116/0000-0003-A0EC-E http://hdl.handle.net/21.11116/0000-0005-63DC-4 |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.E233E0A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |