Academic Journal
New Tumor Budding Evaluation in Head and Neck Squamous Cell Carcinomas
| العنوان: | New Tumor Budding Evaluation in Head and Neck Squamous Cell Carcinomas |
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| المؤلفون: | Claudio Cacchi, Henrike J. Fischer, Kai Wermker, Ashkan Rashad, Danny D. Jonigk, Frank Hölzle, Maurice Klein |
| المصدر: | Cancers, Vol 16, Iss 3, p 587 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | tumor budding, oral cancer, HNSCC, cancer, tumor marker, tumor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background: Tumor budding (TB) is a histomorphological characteristic of the tumor invasion front and it has an impact on the tumor outcome prediction for head and neck squamous cell carcinoma (HNSCC) aetiopathology. Patients and methods: The average TB score (TB rel) of all tumor-positive marginal sections (n = 443) in the primary tumor was analyzed in the FFPE-fixed tumor slices of 66 patients with HNSCC, and they were compared with cryo-fixed sections. Results: TB rel correlates with tumor aggressiveness (i.e., lymph node metastasis quantity, lymph node ratio, extra capsular growth, Pn1, pV1, grading). The TB scores often vary between the different tumor margins of FFPE sections in the same patient, and in many cases, they differ depending on the fixation method. Conclusion: Our data show that a randomly selected marginal cut cannot reliably mirror the TB score, and thus, they cannot predict the prognostic outcome. However, TB rel could be a tool that compensates for differences in TB score analysis. TB score determination in cryo sections seems to be inaccurate compared with TB determination in FFPE. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6694 |
| Relation: | https://www.mdpi.com/2072-6694/16/3/587; https://doaj.org/toc/2072-6694; https://doaj.org/article/bb2c8204bf3640e38f07806d137702f7 |
| DOI: | 10.3390/cancers16030587 |
| الاتاحة: | https://doi.org/10.3390/cancers16030587 https://doaj.org/article/bb2c8204bf3640e38f07806d137702f7 |
| رقم الانضمام: | edsbas.E20A878C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
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| DOI: | 10.3390/cancers16030587 |