Academic Journal
A role for the Ras signalling pathway in synaptic transmission and long-term memory
| العنوان: | A role for the Ras signalling pathway in synaptic transmission and long-term memory |
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| المؤلفون: | R. Brambilla, N. Gnesutta, L. Minichiello, G. White, A. J. Roylance, C. E. Herron, M. Ramsey, D. P. Wolfer, V. Cestari, C. Rossi Arnaud, S. G. N. Grant, P. F. Chapman, H. P. Lipp, E. Sturani, R. Klein |
| المساهمون: | R. Brambilla, N. Gnesutta, L. Minichiello, G. White, A.J. Roylance, C.E. Herron, M. Ramsey, D.P. Wolfer, V. Cestari, C. Rossi Arnaud, S.G.N. Grant, P.F. Chapman, H.P. Lipp, E. Sturani, R. Klein |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 1997 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Muscarinic receptor, exchange factor, protein, potentiation, activation, amygdala, mice, identification, plasticity, induction, Settore BIO/10 - Biochimica |
| الوصف: | Members of the Ras subfamily of small guanine-nucleotide-binding proteins are essential for controlling normal and malignant cell proliferation as well as cell differentiation. The neuronal-specific guanine-nucleotide-exchange factor, Ras-GRF/CDC25Mm, induces Ras signalling in response to Ca2+ influx and activation of G-protein-coupled receptors in vitro, suggesting that it plays a role in neurotransmission and plasticity in vivo. Here we report that mice lacking Ras-GRF are impaired in the process of memory consolidation, as revealed by emotional conditioning tasks that require the function of the amygdala; learning and short-term memory are intact. Electrophysiological measurements in the basolateral amygdala reveal that long-term plasticity is abnormal in mutant mice. In contrast, Ras-GRF mutants do not reveal major deficits in spatial learning tasks such as the Morris water maze, a test that requires hippocampal function. Consistent with apparently normal hippocampal functions, Ras-GRF mutants show normal NMDA (N-methyl-D-aspartate) receptor-dependent long-term potentiation in this structure. These results implicate Ras-GRF signalling via the Ras/MAP kinase pathway in synaptic events leading to formation of long-term memories. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/9384379; info:eu-repo/semantics/altIdentifier/wos/WOS:A1997YG66700062; volume:390; issue:6657; firstpage:281; lastpage:286; numberofpages:6; journal:NATURE; http://hdl.handle.net/2434/139951; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0031581209 |
| DOI: | 10.1038/36849 |
| الاتاحة: | http://hdl.handle.net/2434/139951 https://doi.org/10.1038/36849 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.E1E7BCDF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/36849 |
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