Academic Journal
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities
| العنوان: | The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities |
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| المؤلفون: | Marco Robello, Elisabetta Barresi, Emma Baglini, Silvia Salerno, Sabrina Taliani, Federico Da Settimo |
| المساهمون: | Robello, Marco, Barresi, Elisabetta, Baglini, Emma, Salerno, Silvia, Taliani, Sabrina, DA SETTIMO PASSETTI, Federico |
| سنة النشر: | 2021 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| الوصف: | Over the years, researchers in drug discovery have taken advantage of the use of privileged structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many natural products, and it has been widely exploited by medicinal chemists to develop compounds tailored to a vast range of biological targets, thus presenting clinical potential for a plethora of pathological conditions. The purpose of this perspective is to provide insights into the versatility of this chemical moiety as a privileged structure in drug discovery. After a brief analysis of its physical-chemical features and synthetic procedures to obtain it, α-ketoamide-based classes of compounds are reported according to the application of this motif as either a nonreactive or reactive moiety. The goal is to highlight those aspects that may be useful to understanding the perspectives of employing the α-ketoamide moiety in the rational design of compounds able to interact with a specific target. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000639043300002; volume:64; firstpage:3508; lastpage:3545; numberofpages:38; journal:JOURNAL OF MEDICINAL CHEMISTRY; https://hdl.handle.net/11568/1104203; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85104047991 |
| DOI: | 10.1021/acs.jmedchem.0c01808 |
| الاتاحة: | https://hdl.handle.net/11568/1104203 https://doi.org/10.1021/acs.jmedchem.0c01808 https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01808 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E1E5F7AE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.jmedchem.0c01808 |
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