Academic Journal
Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure
| العنوان: | Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure |
|---|---|
| المؤلفون: | Colciago, Alessandra, Audano, Matteo, Bonalume, Veronica, Melfi, Valentina, Mohamed, Tasnim, Reid, Adam J., Faroni, Alessandro, Greer, Peter A., Mitro, Nico, Magnaghi, Valerio |
| المصدر: | eissn: 2073-4409 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | University of Chester: Chester Digital Repository |
| مصطلحات موضوعية: | Schwann cell, NF2, GJB2, hearing loss, NEFL, TPRN, OTOGL, REST |
| الوصف: | From MDPI via Jisc Publications Router ; History: accepted 2021-07-18, pub-electronic 2021-07-20 ; Publication status: Published ; Funder: Capita Foundation; Grant(s): grant 2019 to V.M. ; Funder: Università degli Studi di Milano; Grant(s): grant PSR_VMAGN_2019 to V.M ; Funder: MIUR Italian Ministry of Research; Grant(s): Progetto di Eccellenza ; Hearing loss (HL) is the most common sensory disorder in the world population. One common cause of HL is the presence of vestibular schwannoma (VS), a benign tumor of the VIII cranial nerve, arising from Schwann cell (SC) transformation. In the last decade, the increasing incidence of VS has been correlated to electromagnetic field (EMF) exposure, which might be considered a pathogenic cause of VS development and HL. Here, we explore the molecular mechanisms underlying the biologic changes of human SCs and/or their oncogenic transformation following EMF exposure. Through NGS technology and RNA-Seq transcriptomic analysis, we investigated the genomic profile and the differential display of HL-related genes after chronic EMF. We found that chronic EMF exposure modified the cell proliferation, in parallel with intracellular signaling and metabolic pathways changes, mostly related to translation and mitochondrial activities. Importantly, the expression of HL-related genes such as NEFL, TPRN, OTOGL, GJB2, and REST appeared to be deregulated in chronic EMF exposure. In conclusion, we suggest that, at a preclinical stage, EMF exposure might promote the transformation of VS cells and contribute to HL. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://chesterrep.openrepository.com/bitstream/handle/10034/625351/cells-10-01840-v2.pdf?sequence=2; https://chesterrep.openrepository.com/bitstream/handle/10034/625351/additional-files.zip?sequence=3; https://chesterrep.openrepository.com/bitstream/handle/10034/625351/cells-10-01840.xml?sequence=4; Cells, volume 10, issue 7, page e1840; http://hdl.handle.net/10034/625351 |
| الاتاحة: | http://hdl.handle.net/10034/625351 https://chesterrep.openrepository.com/bitstream/handle/10034/625351/cells-10-01840-v2.pdf?sequence=2 https://chesterrep.openrepository.com/bitstream/handle/10034/625351/additional-files.zip?sequence=3 https://chesterrep.openrepository.com/bitstream/handle/10034/625351/cells-10-01840.xml?sequence=4 |
| Rights: | Licence for this article: https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.E1CB7918 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |