Academic Journal
Halogen-Mediated Partial Oxidation of Polyvinyl Alcohol for Tissue Engineering Purposes
| العنوان: | Halogen-Mediated Partial Oxidation of Polyvinyl Alcohol for Tissue Engineering Purposes |
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| المؤلفون: | Barbon S., Stocco E., Dalzoppo D., Todros S., Canale A., Boscolo-Berto R., Pavan P., Macchi V., Grandi C., Caro R., Porzionato A. |
| المساهمون: | Barbon, S., Stocco, E., Dalzoppo, D., Todros, S., Canale, A., Boscolo-Berto, R., Pavan, P., Macchi, V., Grandi, C., Caro, R., Porzionato, A. |
| بيانات النشر: | NLM (Medline) |
| سنة النشر: | 2020 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | chemical oxidation, halogen, polyvinyl alcohol, scaffold, tissue engineering |
| الوصف: | Partial oxidation of polyvinyl alcohol (PVA) with potassium permanganate turned out to be an efficient method to fabricate smart scaffolds for tissue engineering, endowed with biodegradation and protein delivery capacity. This work considered for the first time the use of halogens (bromine, chlorine and iodine) as less aggressive agents than potassium permanganate to perform controlled PVA oxidation, in order to prevent degradation of polymer molecular size upon chemical modification. Oxidized PVA solutions were chemically characterized (i.e., dinitrophenylhydrazine assay, viscosity measurements, molecular size distribution) before preparing physically cross-linked hydrogels. Scaffolds were assessed for their mechanical properties and cell/tissue biocompatibiliy through cytotoxic extract test on IMR-90 fibroblasts and subcutaneous implantation into BALB/c mice. According to chemical investigations, bromine and iodine allowed for minor alteration of polymer molecular weight. Uniaxial tensile tests demonstrated that oxidized scaffolds had decreased mechanical resistance to deformation, suggesting tunable hydrogel stiffness. Finally, oxidized hydrogels exhibited high biocompatibility both in vitro and in vivo, resulting neither to be cytotoxic nor to elicit severe immunitary host reaction in comparison with atoxic PVA. In conclusion, PVA hydrogels oxidized by halogens were successfully fabricated in the effort of adapting polymer characteristics to specific tissue engineering applications. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31991838; info:eu-repo/semantics/altIdentifier/wos/WOS:000522551602014; volume:21; issue:3; firstpage:801; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11577/3333875; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85078687615 |
| DOI: | 10.3390/ijms21030801 |
| الاتاحة: | http://hdl.handle.net/11577/3333875 https://doi.org/10.3390/ijms21030801 |
| رقم الانضمام: | edsbas.E1AA2DDF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms21030801 |
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