Academic Journal
Preventing cervical cancer using HPV self-sampling:Direct mailing of test-kits increases screening participation more than timely opt-in procedures - a randomized controlled trial
| العنوان: | Preventing cervical cancer using HPV self-sampling:Direct mailing of test-kits increases screening participation more than timely opt-in procedures - a randomized controlled trial |
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| المؤلفون: | Tranberg, Mette, Bech, Bodil Hammer, Blaakær, Jan, Jensen, Jørgen Skov, Svanholm, Hans, Andersen, Berit |
| المصدر: | Tranberg , M , Bech , B H , Blaakær , J , Jensen , J S , Svanholm , H & Andersen , B 2018 , ' Preventing cervical cancer using HPV self-sampling : Direct mailing of test-kits increases screening participation more than timely opt-in procedures - a randomized controlled trial ' , BMC Cancer , vol. 18 , 273 . https://doi.org/10.1186/s12885-018-4165-4 |
| سنة النشر: | 2018 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | Cancer prevention, Cervical cancer screening, Human papillomavirus testing, Screening participation, Self-sampling, Prevalence, Prognosis, Follow-Up Studies, Humans, Middle Aged, Patient Participation, Papillomaviridae/isolation & purification, Specimen Handling, Cervical Intraepithelial Neoplasia/diagnosis, Uterine Cervical Neoplasms/diagnosis, Adult, Female, Postal Service/statistics & numerical data, Vaginal Smears, Papillomavirus Infections/complications, Early Detection of Cancer/methods, Denmark/epidemiology, Intention to Treat Analysis, Research Design, Self Care |
| الوصف: | BACKGROUND: Cervical cancer screening participation remains insufficient in most countries. Our aim was to evaluate whether offering a HPV self-sampling kit, either mailed directly to the woman's home or using timely opt-in procedures for ordering the kit, increased screening participation compared with a standard second reminder. METHODS: In this randomized, controlled effectiveness trial, 9791 Danish women aged 30-64 who were due to receive the second reminder were equally randomized to either: 1) direct mailing of a second reminder and a self-sampling kit (directly mailed group); 2) mailing of a second reminder that offered a self-sampling kit to be ordered by e-mail, text message, phone, or webpage (opt-in group); or 3) mailing of a second reminder to attend regular cytology screening (control group). In an intention-to-treat analysis, we estimated the participation rate at 180 days post intervention, by returning a self-sample or attending regular cytology screening. We calculated the proportion of women with a positive HPV self-sample who attended for cervical cytology triage at the general practitioner within 90 days. RESULTS: Participation was significantly higher in the directly mailed group (38.0%) and in the opt-in group (30.9%) than in the control group (25.2%) (participation difference (PD): 12.8%, 95% CI: 10.6-15.0% and PD: 5.7%, 95% CI: 3.5-7.9%, respectively). Within 90 days, 107 women (90.7%, 95% CI: 83.9-95.3%) with a HPV-positive self-sample attended follow-up. CONCLUSIONS: Offering the opportunity of HPV self-sampling as an alternative to regular cytology screening increased participation; the direct mailing strategy was the most effective invitation strategy. A high compliance with follow-up was seen. TRIAL REGISTRATION: Current Controlled Trials NCT02680262 . Registered 10 February 2016. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1186/s12885-018-4165-4 |
| الاتاحة: | https://portal.findresearcher.sdu.dk/da/publications/df3622ee-cab1-47ab-8b7a-b4de8e791528 https://doi.org/10.1186/s12885-018-4165-4 https://findresearcher.sdu.dk/ws/files/141342960/Preventing_cervical_cancer_using_HPV_self_sampling.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E1A176CB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12885-018-4165-4 |
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