Academic Journal
Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling
| العنوان: | Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling |
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| المؤلفون: | d'Angelo, Gisela, Matusek, Tamás, Pizette, Sandrine, Thérond, Pascal p. |
| المساهمون: | Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA), ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011) |
| المصدر: | ISSN: 1534-5807 ; Developmental Cell ; https://hal.science/hal-03033949 ; Developmental Cell, 2015, 32 (3), pp.290-303. ⟨10.1016/j.devcel.2014.12.004⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2015 |
| المجموعة: | HAL Université Côte d'Azur |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; The proteins of the Hedgehog (Hh) family are secreted proteins exerting short- and long-range control over various cell fates in developmental patterning. The Hh gradient in Drosophila wing imaginal discs consists of apical and basolateral secreted pools, but the mechanisms governing the overall establishment of the gradient remain unclear. We investigated the relative contributions of endocytosis and recycling to control the Hh gradient. We show that, upon its initial apical secretion, Hh is re-internalized. We examined the effect of the resistance-nodulation-division transporter Dispatched (Disp) on long-range Hh signaling and unexpectedly found that Disp is specifically required for apical endocytosis of Hh. Re-internalized Hh is then regulated in a Rab5- and Rab4-dependent manner to ensure its long-range activity. We propose that Hh-producing cells integrate endocytosis and recycling as two instrumental mechanisms contributing to regulate the long-range activity of Hh. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/25619925; hal-03033949; https://hal.science/hal-03033949; https://hal.science/hal-03033949/document; https://hal.science/hal-03033949/file/d%27angelo%20et%20al.,%202015.pdf; PUBMED: 25619925 |
| DOI: | 10.1016/j.devcel.2014.12.004 |
| الاتاحة: | https://hal.science/hal-03033949 https://hal.science/hal-03033949/document https://hal.science/hal-03033949/file/d%27angelo%20et%20al.,%202015.pdf https://doi.org/10.1016/j.devcel.2014.12.004 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E16074AF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.devcel.2014.12.004 |
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