Academic Journal
Decreased NKCC1 Activity in Erythrocytes From African Americans With Hypertension and Dyslipidemia
| العنوان: | Decreased NKCC1 Activity in Erythrocytes From African Americans With Hypertension and Dyslipidemia |
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| المؤلفون: | Orlov, Sergei N., Gossard, Francis, Pausova, Zdenka, Akimova, Olga A., Tremblay, Johanne, Grim, Clarence E., Kotchen, Jane M., Kotchen, Theodore A., Gaudet, Daniel, Cowley, Allen W., Hamet, Pavel |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2010 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Original Contributions |
| الوصف: | Background Recent studies demonstrated a key role of ubiquitous isoform of Na+,K+,2Cl− co-transport (NKCC1) in regulation of myogenic tone and peripheral resistance. We examined the impact of race, gender, and plasma lipid on NKCC1 activity in French Canadians and African Americans with hypertension and dyslipidemia. Methods NKCC and passive erythrocyte membrane permeability to K+, measured as ouabain-resistant, bumetanide-sensitive, and (ouabain+bumetanide)-resistant 86Rb influx, respectively, were compared in 111 French-Canadian men, 107 French-Canadian women, 26 African-American men, and 45 African-American women with essential hypertension and dyslipidemia. Results The African-American men and women were 7 years younger and presented twofold decreased plasma triglycerides compared to their French-Canadian counterparts ( P < 0.01) whereas body mass index (BMI), total cholesterol, low-density lipoprotein, and high-density lipoprotein (HDL) were not different. NKCC was respectively 50 and 38% lower in the African-American men and women than in the French Canadians ( P < 0.005) without any differences in passive erythrocyte membrane permeability for K+. We did not observe any impact of age on NKCC in all groups under investigation, whereas plasma triglycerides correlated positively with the activity of this carrier in the French-Canadian men only. Conclusions NKCC1 activity is lower in erythrocytes of African Americans with essential hypertension and dyslipidemia than in Caucasian counterparts. We suggest that decreased NKCC1 may contribute to the feature of the pathogenesis of salt-sensitive hypertension seen in African Americans. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://ajh.oxfordjournals.org/cgi/content/short/23/3/321; http://dx.doi.org/10.1038/ajh.2009.249 |
| DOI: | 10.1038/ajh.2009.249 |
| الاتاحة: | http://ajh.oxfordjournals.org/cgi/content/short/23/3/321 https://doi.org/10.1038/ajh.2009.249 |
| Rights: | Copyright (C) 2010, American Journal of Hypertension, Ltd. |
| رقم الانضمام: | edsbas.E15F71EE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ajh.2009.249 |
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