Academic Journal
Case definition.
| العنوان: | Case definition. |
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| المؤلفون: | Marion de Lepper, Anna-Janina Stephan, Regine Wölle, Wei Wang, Christian Jacob, Kim Maren Schneider, Horst Buxmann, Rangmar Goelz, Klaus Hamprecht, Peter Kummer, Susanne Modrow, Wolfgang Greiner, Agnes Luzak, Miriam Reuschenbach |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Medicine, Neuroscience, Biotechnology, Evolutionary Biology, Developmental Biology, Cancer, Mental Health, Infectious Diseases, Virology, Computational Biology, outpatient physician visits, motor development disorders, least one sequela, least one inpatient, intrauterine growth retardation, 2014 – 2018, ≤ 90 days, |
| الوصف: | Background Congenital cytomegalovirus (cCMV) infection can have a broad range of manifestations. This study aimed to assess cCMV-associated sequelae and healthcare resource utilization (HCRU) in infants during the first year of life in Germany. Methods A retrospective, controlled cohort study using German claims data from the Institute for Applied Health Research Berlin (InGef) database was conducted. cCMV-associated sequelae and HCRU during the first year of life were assessed by matching (1:60) infants with at least one inpatient/outpatient cCMV diagnosis (ICD-10-GM: P35.1) ≤90 days after birth (cCMV 90 cohort) and infants with at least one inpatient cCMV diagnosis plus specific sequelae ≤21 days after birth (cCMV 21-S ) to infants without cCMV or CMV (ICD-10-GM: B25) diagnosis (control group), respectively. Outcomes were analyzed during the first 365 days of life. Results Between 2014–2018, we identified 54 newborns for cCMV 90 and 24 newborns for cCMV 21-S cohort. Compared to the 3,240 and 1,440 controls, respectively, more cCMV 90 infants (83.3% vs. 41.9%, p<0.01) presented with at least one sequela during the first year of life, including intrauterine growth retardation (42.6% vs. 5.3%, p<0.01), sensorineural hearing loss (SNHL) to deafness (38.9% vs. 2.2%, p<0.01), and motor development disorders (33.3% vs. 10.9%, p<0.01). Further, 13.0% of cCMV 90 infants (vs. 2.3%, p<0.01) suffered from visual impairment. In cCMV 21-S cohort, intrauterine growth retardation (79.2% vs. 6.0%, p<0.01), prematurity (54.2% vs. 7.3%, p<0.01), and motor development disorders (50.0% vs. 11.0%, p<0.01) were the most frequent sequelae. Infants in the cCMV 90 and cCMV 21-S cohort had, on average, 7.3 times and 9.5 times more hospitalizations and 2.0 times and 2.1 times more outpatient physician visits than their respective controls (p<0.01). Hospitalized infants with cCMV stayed, on average, significantly longer in hospital compared to their controls (cCMV 90 cohort: 30.3 days vs. 9.0 days, p<0.01; ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Case_definition_/24577553 |
| DOI: | 10.1371/journal.pone.0293869.s001 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0293869.s001 https://figshare.com/articles/journal_contribution/Case_definition_/24577553 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.E10597FA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0293869.s001 |
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