Academic Journal
Oestrogen‐Induced Activation of Preoptic Kisspeptin Neurones May be Involved in the Luteinising Hormone Surge in Male and Female Japanese Monkeys
| العنوان: | Oestrogen‐Induced Activation of Preoptic Kisspeptin Neurones May be Involved in the Luteinising Hormone Surge in Male and Female Japanese Monkeys |
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| المؤلفون: | Watanabe, Y., Uenoyama, Y., Suzuki, J., Takase, K., Suetomi, Y., Ohkura, S., Inoue, N., Maeda, K.‐I., Tsukamura, H. |
| المساهمون: | Japan Society for the Promotion of Science, Cooperation Research Program of Primate Research Institute, Kyoto University |
| المصدر: | Journal of Neuroendocrinology ; volume 26, issue 12, page 909-917 ; ISSN 0953-8194 1365-2826 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2014 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The oestrogen‐induced luteinising hormone ( LH ) surge is evident in male primates, including humans, whereas male rodents never show the LH surge, even when treated with a preovulatory level of oestrogen. This suggests that the central mechanism governing reproductive hormones in primates is different from that in rodents. The present study aimed to investigate whether male Japanese monkeys conserve a brain mechanism mediating the oestrogen‐induced LH surge via activation of kisspeptin neurones. Adult male and female Japanese monkeys were gonadectomised and then were treated with oestradiol‐17β for 2 weeks followed by a bolus injection of oestradiol benzoate. Both male and female monkeys showed an oestrogen‐induced LH surge. In gonadectomised monkeys sacrificed just before the anticipated time of the LH surge, oestrogen treatment significantly increased the number of KISS 1 ‐expressing cells in the preoptic area ( POA ) and enhanced the expression of c‐ fos in POA KISS 1 ‐positive cells of males and females. The oestrogen treatment failed to induce c‐ fos expression in the arcuate nucleus ( ARC ) kisspeptin neurones in both sexes just prior to LH surge onset. Thus, kisspeptin neurones in the POA but not in the ARC might be involved in the positive‐feedback action of oestrogen that induces LH surge in male Japanese monkeys, as well as female monkeys. The present results indicate that oestrogen‐induced activation of POA kisspeptin neurones may contribute to the LH surge generation in both sexes. The conservation of the LH surge generating system found in adult male primates, unlike rodents, could be a result of the capability of oestrogen to induce POA kisspeptin expression and activation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/jne.12227 |
| الاتاحة: | http://dx.doi.org/10.1111/jne.12227 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjne.12227 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jne.12227 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.E0D38145 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jne.12227 |
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