التفاصيل البيبلوغرافية
| العنوان: |
DataSheet_1_Herpes DNAemia and TTV Viraemia in Intensive Care Unit Critically Ill Patients: A Single-Centre Prospective Longitudinal Study.docx |
| المؤلفون: |
François Mallet (15409), Léa Diouf (11634715), Boris Meunier (6712508), Magali Perret (354757), Frédéric Reynier (201072), Philippe Leissner (21314), Laurence Quemeneur (11634718), Andrew D. Griffiths (1898392), Virginie Moucadel (29798), Alexandre Pachot (432812), Fabienne Venet (432807), Guillaume Monneret (329582), Alain Lepape (432813), Thomas Rimmelé (3550463), Lionel K. Tan (11634721), Karen Brengel-Pesce (5486522), Julien Textoris (185259) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, herpesviruses, TTV, intensive care unit, sepsis, mortality, acquired infection, immune response, biomarkers |
| الوصف: |
Introduction We analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, and HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort of critically ill patients who had presented with either sepsis, burns, severe trauma, or major surgery. The aim was to identify common features related to virus and injury-associated pathologies and specific features linking one or several viruses to a particular pathological context. Methods Overall and individual viral DNAemia were measured over a month using quantitative PCR assays from the 377 patients in the REALISM cohort. These patients were characterised by clinical outcomes [severity scores, mortality, Intensive Care Unit (ICU)-acquired infection (IAI)] and 48 parameters defining their host response after injury (cell populations, immune functional assays, and biomarkers). Association between viraemic event and clinical outcomes or immune markers was assessed using χ 2 -test or exact Fisher’s test for qualitative variables and Wilcoxon test for continuous variables. Results The cumulative incidence of viral DNAemia increased from below 4% at ICU admission to 35% for each herpesvirus during the first month. EBV, HSV1, HHV6, and CMV were detected in 18%, 12%, 10%, and 9% of patients, respectively. The incidence of high TTV viraemia (>10,000 copies/ml) increased from 11% to 15% during the same period. Herpesvirus viraemia was associated with severity at admission; CMV and HHV6 viraemia correlated with mortality during the first week and over the month. The presence of individual herpesvirus during the first month was significantly associated (p < 0.001) with the occurrence of IAI, whilst herpesvirus DNAemia coupled with high TTV viraemia during the very first week was associated with IAI. Herpesvirus viraemia was associated with a lasting exacerbated host immune response, with concurrent profound immune suppression and hyper inflammation, and delayed return to immune homeostasis. The percentage of patients presenting with herpesvirus DNAemia ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/DataSheet_1_Herpes_DNAemia_and_TTV_Viraemia_in_Intensive_Care_Unit_Critically_Ill_Patients_A_Single-Centre_Prospective_Longitudinal_Study_docx/16917223 |
| DOI: |
10.3389/fimmu.2021.698808.s001 |
| الاتاحة: |
https://doi.org/10.3389/fimmu.2021.698808.s001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.E0C310EB |
| قاعدة البيانات: |
BASE |