Academic Journal
T1-weighted dynamic contrast-enhanced brain magnetic resonance imaging: A preliminary study with low infusion rate in pediatric patients.
| العنوان: | T1-weighted dynamic contrast-enhanced brain magnetic resonance imaging: A preliminary study with low infusion rate in pediatric patients. |
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| المؤلفون: | Rochetams, B.B., Marechal, B., Cottier, J.P., Gaillot, K., Sembely-Taveau, C., Sirinelli, D., Morel, B. |
| المصدر: | The neuroradiology journal, vol. 30, no. 5, pp. 429-436 |
| سنة النشر: | 2017 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Dynamic contrast-enhanced MRI, brain, children, pediatric radiology |
| الوصف: | Background The aim of this preliminary study is to evaluate the results of T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in pediatric patients at 1.5T, with a low peripheral intravenous gadoteric acid injection rate of 1 ml/s. Materials and methods Children with neurological symptoms were examined prospectively with conventional MRI and T1-weighted DCE MRI. An magnetic resonance perfusion analysis method was used to obtain time-concentration curves (persistent pattern, type-I; plateau pattern, type-II; washout pattern, type-III) and to calculate pharmacokinetic parameters. A total of two radiologists manually defined regions of interest (ROIs) in the part of the lesion exhibiting the greatest contrast enhancement and in the surrounding normal or contralateral tissue. Lesion/surrounding tissue or contralateral tissue pharmacokinetic parameter ratios were calculated. Tumors were categorized by grade (I-IV) using the World Health Organization (WHO) Grade. Mann-Whitney testing and receiver-operating characteristic (ROC) curves were performed. Results A total of nine boys and nine girls (mean age 10.5 years) were included. Lesions consisted of 10 brain tumors, 3 inflammatory lesions, 3 arteriovenous malformations and 2 strokes. We obtained analyzable concentration-time curves for all patients (6 type-I, 9 type-II, 3 type-III). K(trans) between tumor tissue and surrounding or contralateral tissue was significantly different ( p = 0.034). K(trans) ratios were significantly different between grade I tumors and grade IV tumors ( p = 0.027) and a K(trans) ratio value superior to 0.63 appeared to be discriminant to determine a grade IV of malignancy. Conclusions Our results confirm the feasibility of pediatric T1-weighted DCE MRI at 1.5T with a low injection rate, which could be of great value in differentiating brain tumor grades. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/28556691; info:eu-repo/semantics/altIdentifier/eissn/2385-1996; https://serval.unil.ch/notice/serval:BIB_78C7159C5575 |
| DOI: | 10.1177/1971400917709626 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_78C7159C5575 https://doi.org/10.1177/1971400917709626 |
| رقم الانضمام: | edsbas.E0BF524D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1971400917709626 |
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