Academic Journal
Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study.
| العنوان: | Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study. |
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| المؤلفون: | Carugati, Manuela, Arif, Sana, Sudan, Debra Lynn, Collins, Bradley Henry, Haney, John Carroll, Schroder, Jacob Niall, Reynolds, John Michael, Lewis, Sarah Stamps, Yarrington, Michael Edwards, Miller, Rachel Ann, Alexander, Barbara Dudley |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2022 |
| المجموعة: | Duke University Libraries: DukeSpace |
| مصطلحات موضوعية: | clinical research / practice, complication: infectious, infection - mycobacterial: nontuberculous, infection and infectious agents - bacterial, infection and infectious agents - fungal, infectious disease |
| الوصف: | Surgical site infections (SSI) are severe complications of solid organ transplant (SOT). This retrospective study assessed the epidemiology of and outcomes associated with invasive primary SSI (IP-SSI) occurring within 3 months of transplantation in adult SOT recipients at Duke University over a 5-year period (2015-2019). Among 2073 consecutive SOT recipients, 198 IP-SSI were identified. The IP-SSI rate declined over the period (14.4% in 2015 vs. 8.3% in 2019) and was higher among multi-organ compared with single-organ transplants (33.9% vs. 8.1%, p < .01). SOT recipients with IP-SSI had longer hospital stays than patients without SSI (30.0 vs. 17.0 days, p < .01). Transplant hospitalization (9.6% vs. 2.2%, p < .01), 6-month (11.6% vs. 3.3%, p < .01), and 1-year mortality (15.7% vs. 5.8%, p < .01) were higher in SOT recipients with IP-SSI than in those without. While Gram-positive bacteria were the most common pathogens, urogenital Mollicute and atypical Mycobacteria were identified as an unexpected cause of IP-SSI, particularly among lung transplant recipients. The median time to IP-SSI was 24.0 (IQR 13.8-48.3) days, although the time to IP-SSI varied based on organ transplanted and the causative pathogen. IP-SSI is an important and potentially modifiable complication of SOT, associated with prolonged hospitalizations and reduced survival, particularly in the lung transplant population. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1600-6135 1600-6143 |
| Relation: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons; https://hdl.handle.net/10161/26020 |
| الاتاحة: | https://hdl.handle.net/10161/26020 |
| رقم الانضمام: | edsbas.E07B5135 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16006135 16006143 |
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