Academic Journal
Palladium/Norbornene Cooperative Catalysis Bifunctionalization: Acylation/Cyanation of Aryl Iodides by Cleaving C–CN Bond of Aryl Acyl Nitrile
| العنوان: | Palladium/Norbornene Cooperative Catalysis Bifunctionalization: Acylation/Cyanation of Aryl Iodides by Cleaving C–CN Bond of Aryl Acyl Nitrile |
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| المؤلفون: | Hang Liu, Yi-Xin Chai, Jun-Jie Yang, Dan Miao, Meng-Yao Wang, Ting Jiang, Yuan-Yuan Sun, Xin Lu, Qing Sun, Jin-Heng Li, Yan-Ping Zhu |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Microbiology, Cell Biology, Pharmacology, Biotechnology, Ecology, Hematology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, synthetic protocol demonstrated, important nbe derivatives, >- substituted isoindolinones, norbornene catalyzed two, aryl acyl nitrile, catalyzed cleavage, aryl iodides, acyl sources, wide range, termination reagent, smoothly obtained, products resulting, good application, first example, electrophilic reagent, cleverly selected |
| الوصف: | A palladium/norbornene catalyzed two-component coupling process involving acylation/cyanation of aryl iodides is reported. In this work, aryl acyl nitrile compounds are cleverly selected to provide both nitrile and acyl sources by palladium-catalyzed cleavage of the C–CN bond as both an electrophilic reagent and a termination reagent. This is the first example of C–CN bond cleavage bifunctionalization of aryl iodides. After a series of important NBE derivatives are screened, the products resulting from the bifunctionalization of aryl iodides are smoothly obtained. This strategy has a wide range of substrates and good functional group compatibility. Moreover, this synthetic protocol demonstrated a good application for the synthesis of diverse O , N , C -substituted isoindolinones. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Palladium_Norbornene_Cooperative_Catalysis_Bifunctionalization_Acylation_Cyanation_of_Aryl_Iodides_by_Cleaving_C_CN_Bond_of_Aryl_Acyl_Nitrile/24970251 |
| DOI: | 10.1021/acs.orglett.3c03838.s001 |
| الاتاحة: | https://doi.org/10.1021/acs.orglett.3c03838.s001 https://figshare.com/articles/journal_contribution/Palladium_Norbornene_Cooperative_Catalysis_Bifunctionalization_Acylation_Cyanation_of_Aryl_Iodides_by_Cleaving_C_CN_Bond_of_Aryl_Acyl_Nitrile/24970251 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.E0511891 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.orglett.3c03838.s001 |
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