Academic Journal
Biodegradable scaffolds for bone regeneration combined with drug-delivery systems in osteomyelitis therapy
| العنوان: | Biodegradable scaffolds for bone regeneration combined with drug-delivery systems in osteomyelitis therapy |
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| المؤلفون: | Dorati, Rossella, DeTrizio, Antonella, Modena, Tiziana, Conti, Bice, Benazzo, Francesco, Gastaldi, Giulia, Genta, Ida |
| المساهمون: | Dorati, Rossella, Detrizio, Antonella, Modena, Tiziana, Conti, Bice, Benazzo, Francesco, Gastaldi, Giulia, Genta, Ida |
| سنة النشر: | 2017 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | Antibiotic, Bone regeneration, Gentamicin, Osteomyeliti, Scaffold, Molecular Medicine |
| Time: | 3003 |
| الوصف: | great deal of research is ongoing in the area of tissue engineering (TE) for bone regeneration. A possible improvement in restoring damaged tissues involves the loading of drugs such as proteins, genes, growth factors, antibiotics, and anti-inflammatory drugs into scaffolds for tissue regeneration. This mini-review is focused on the combination of the local delivery of antibiotic agents with bone regenerative therapy for the treatment of a severe bone infection such as osteomyelitis. The review includes a brief explanation of scaffolds for bone regeneration including scaffolds characteristics and types, a focus on severe bone infections (especially osteomyelitis and its treatment), and a literature review of local antibiotic delivery by the combination of scaffolds and drug-delivery systems. Some examples related to published studies on gentamicin sulfate-loaded drug-delivery systems combined with scaffolds are discussed, and future perspectives are highlighted. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/29231857; info:eu-repo/semantics/altIdentifier/wos/WOS:000419241100018; volume:10; issue:4; firstpage:96; journal:PHARMACEUTICALS; http://hdl.handle.net/11571/1213428; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85038074735; http://www.mdpi.com/1424-8247/10/4/96/pdf |
| DOI: | 10.3390/ph10040096 |
| الاتاحة: | http://hdl.handle.net/11571/1213428 https://doi.org/10.3390/ph10040096 http://www.mdpi.com/1424-8247/10/4/96/pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E02A2F10 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ph10040096 |
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