Academic Journal
Impact of SARS-CoV-2 genetic variants on hospitalization of patients with COVID-19 from the national surveillance of the Nicaraguan Ministry of Health, March 2020 - September 2022 ; Impacto de las variantes genéticas del SARS-CoV-2 en la hospitalización de pacientes con COVID-19 procedentes de la vigilancia nacional del Ministerio de Salud de Nicaragua, marzo 2020 – septiembre 2022
| العنوان: | Impact of SARS-CoV-2 genetic variants on hospitalization of patients with COVID-19 from the national surveillance of the Nicaraguan Ministry of Health, March 2020 - September 2022 ; Impacto de las variantes genéticas del SARS-CoV-2 en la hospitalización de pacientes con COVID-19 procedentes de la vigilancia nacional del Ministerio de Salud de Nicaragua, marzo 2020 – septiembre 2022 |
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| المؤلفون: | Vásquez Alemán, Gerald, Cerpas Cruz, Christiam, Moreira Tijerino, Hanny, Mayorga-Marín, Francisco, Juárez, José, Arguello, Sonia, Harris, Eva, Gordon, Aubree, Balmaseda, Ángel |
| المصدر: | Revista Científica de la FAREM-Estelí; No. 50 (2024); 70-85 ; Revista Científica Estelí; Núm. 50 (2024); 70-85 ; 3006-6700 |
| بيانات النشر: | Centro Universitario Regional Estelí, CUR-Estelí, UNAN-Managua |
| سنة النشر: | 2024 |
| المجموعة: | Central American Journals Online |
| مصطلحات موضوعية: | SARS CoV-2, COVID-19, secuenciation, RT-PCR, secuenciación |
| الوصف: | SARS-CoV-2 spread rapidly around the world, causing high morbidity and mortality, making genome sequencing essential. Numerous studies have shown how variants can influence hospitalization. This study aimed to identify the impact of SARS-CoV-2 genetic variants on the probability of hospitalization. A total of 1069 samples from COVID-19 patients across the country were sequenced using Illumina and Oxford Nanopore technologies. Descriptive analyses and logistic regression models were performed to determine associations between virus characteristics and the risk of hospitalization. The main results showed that the most frequent variants were Omicron and Delta (21.32%) and 19B (21.2%). The less common variants were 21C (Epsilon) and 21H (Mu). Mutations were identified in the N, M, ORFs, and S regions of the SARS-CoV-2 genome, including the S:D614G mutation. Significant differences were found in the age of people infected with different variants. There was a negative association between increasing age and the risk of infection with the 19B variant, and a positive association with the 20B and Delta variants. Additionally, associations were found between the 20A, 20B, 20C, and Delta variants and the risk of hospitalization. Age was a determining factor in the risk of infection by certain variants. Some variants increased the risk of hospitalization, and age, in combination with the genetic characteristics of the variants, influenced this risk. The study concludes that mutations of epidemiological importance were identified, especially the S:D614G mutation, and that certain mutations and genetic characteristics of the virus can confer a higher risk of hospitalization. ; El SARS-CoV-2 se propagó rápidamente por el mundo causando alta morbilidad y mortalidad, por lo que la secuenciación de su genoma se volvió esencial. Numerosos estudios han mostrado cómo las variantes pueden influir en la hospitalización. Este estudio buscó identificar el impacto de las variantes genéticas del SARS-CoV-2 en la probabilidad de ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/html |
| اللغة: | Spanish; Castilian |
| Relation: | https://www.camjol.info/index.php/FAREM/article/view/18474/22300; https://www.camjol.info/index.php/FAREM/article/view/18474/22301; https://www.camjol.info/index.php/FAREM/article/view/18474 |
| DOI: | 10.5377/esteli.v13i50.18474 |
| الاتاحة: | https://www.camjol.info/index.php/FAREM/article/view/18474 https://doi.org/10.5377/esteli.v13i50.18474 |
| Rights: | Derechos de autor 2024 Revista Científica Estelí ; http://creativecommons.org/licenses/by-nc-sa/4.0 |
| رقم الانضمام: | edsbas.E0204243 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5377/esteli.v13i50.18474 |
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