Academic Journal
The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia
| العنوان: | The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia |
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| المؤلفون: | García Partida, José Antonio, Torres Sánchez, Sonia, MacDowell, Karina S., Fernández Ponce, María Teresa, Casas Cardoso, Lourdes, Mantell Serrano, Casimiro, Soto-Montenegro, María Luisa, Romero-Miguel, Diego, Lamanna-Rama, Nicolás, Leza, Juan Carlos, Desco, Manuel, Berrocoso Domínguez, Esther María |
| المساهمون: | Ingeniería Química y Tecnología de Alimentos, Psicología |
| المصدر: | Frontiers in Pharmacology, Vol. 13 |
| بيانات النشر: | FRONTIERS MEDIA SA |
| سنة النشر: | 2023 |
| المجموعة: | RODIN - Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz |
| مصطلحات موضوعية: | mangiferin, schizophrenia, Poly I:C, oxidative/nitrosative stress, neuroinflammation, magnetic resonace imaging (MRI) |
| الوصف: | There is evidence that in schizophrenia, imbalances in inflammatory and oxidative processes occur during pregnancy and in the early postnatal period, generating interest in the potential therapeutic efficacy of anti-inflammatory and antioxidant compounds. Mangiferin is a polyphenolic compound abundant in the leaves of Mangifera indica L. that has robust antioxidant and anti-inflammatory properties, making it a potential candidate for preventive or co-adjuvant therapy in schizophrenia. Hence, this study set-out to evaluate the effect of mango leaf extract (MLE) in a model of schizophrenia based on maternal immune activation, in which Poly I:C (4 mg/kg) is administered intravenously to pregnant rats. Young adult (postnatal day 60-70) or adolescent (postnatal day 35-49) male offspring received MLE (50 mg/kg of mangiferin) daily, and the effects of MLE in adolescence were compared to those of risperidone, assessing behavior, brain magnetic resonance imaging (MRI), and oxidative/inflammatory and antioxidant mediators in the adult offspring. MLE treatment in adulthood reversed the deficit in prepulse inhibition (PPI) but it failed to attenuate the sensitivity to amphetamine and the deficit in novel object recognition (NOR) induced. By contrast, adolescent MLE treatment prevented the sensorimotor gating deficit in the PPI test, producing an effect similar to that of risperidone. This MLE treatment also produced a reduction in grooming behavior, but it had no effect on anxiety or novel object recognition memory. MRI studies revealed that adolescent MLE administration partially counteracted the cortical shrinkage, and cerebellum and ventricle enlargement. In addition, MLE administration in adolescence reduced iNOS mediated inflammatory activation and it promoted the expression of biomarkers of compensatory antioxidant activity in the prefrontal cortex and hippocampus, as witnessed through the reduction of Keap1 and the accumulation of NRF2 and HO1. Together, these findings suggest that MLE might be an alternative ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1663-9812 |
| Relation: | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099778-B-I00/ES/DIFERENCIAS SEXUALES EN LA COMORBILIDAD DOLOR CRONICO Y ANSIEDAD: FOCO EN EL LOCUS COERULEUS/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01691/ES/EVALUACION DE LA CAPACIDAD DE MODULACION COGNITIVA EN ESTADOS DE DEPRESION Y DOLOR CRONICO COMO CONSECUENCIA DE CAMBIOS EN LA NEUROGENESIS ADULTA EN HIPOCAMPO Y SU CORRELACION CON LA FUNCIONALIDAD DEL LOCUS COERULEUS./; info:eu-repo/grantAgreement/Junta de Andalucía//PI0080-2017; info:eu-repo/grantAgreement/Junta de Andalucía//PI-0009-2017; info:eu-repo/grantAgreement/Junta de Andalucía//PI-0134-2018; info:eu-repo/grantAgreement/EC/H2020/955684/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116229RB-I00/ES/DISPOSITIVOS POLIMERICOS FUNCIONALES MEDIANTE PROCESOS A ALTA PRESION PARA APLICACIONES BIOMEDICAS/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109033RB-I00/ES/MECANISMOS DE ENTRADA A CEREBRO DE SEÑALES INFLAMATORIAS EN PATOLOGIAS PSIQUIATRICAS/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01766/ES/¿ES POSIBLE PREVENIR EL RIESGO DE APARICION DE LA ESQUIZOFRENIA DURANTE LA GESTACION? ESTUDIOS EN UN MODELO ANIMAL DE ESQUIZOFRENIA/; info:eu-repo/grantAgreement/MINECO//SEV-2015-0505/ES/CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III/; http://hdl.handle.net/10498/27943 |
| DOI: | 10.3389/fphar.2022.886514 |
| الاتاحة: | http://hdl.handle.net/10498/27943 https://doi.org/10.3389/fphar.2022.886514 |
| Rights: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E01FDE36 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16639812 |
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| DOI: | 10.3389/fphar.2022.886514 |