Academic Journal
Cytogenetic follow-up studies on humans with internal and external exposure to ionizing radiation
| العنوان: | Cytogenetic follow-up studies on humans with internal and external exposure to ionizing radiation |
|---|---|
| المؤلفون: | Balajee, Adayabalam S, Livingston, Gordon K, Escalona, Maria B, Ryan, Terri L, Goans, Ronald E, Iddins, Carol J |
| المساهمون: | U.S. Department of Energy |
| المصدر: | Journal of Radiological Protection ; volume 41, issue 4, page S578-S601 ; ISSN 0952-4746 1361-6498 |
| بيانات النشر: | IOP Publishing |
| سنة النشر: | 2021 |
| الوصف: | Cells exposed to ionizing radiation have a wide spectrum of DNA lesions that include DNA single-strand breaks, DNA double-strand breaks (DSBs), oxidative base damage and DNA-protein crosslinks. Among them, DSB is the most critical lesion, which when mis-repaired leads to unstable and stable chromosome aberrations. Currently, chromosome aberration analysis is the preferred method for biological monitoring of radiation-exposed humans. Stable chromosome aberrations, such as inversions and balanced translocations, persist in the peripheral blood lymphocytes of radiation-exposed humans for several years and, therefore, are potentially useful tools to prognosticate the health risks of radiation exposure, particularly in the hematopoietic system. In this review, we summarize the cytogenetic follow-up studies performed by REAC/TS (Radiation Emergency Assistance Center/Training site, Oak Ridge, USA) on humans exposed to internal and external radiation. In the light of our observations as well as the data existing in the literature, this review attempts to highlight the importance of follow-up studies for predicting the extent of genomic instability and its impact on delayed health risks in radiation-exposed victims. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1088/1361-6498/ac125a |
| DOI: | 10.1088/1361-6498/ac125a/pdf |
| الاتاحة: | http://dx.doi.org/10.1088/1361-6498/ac125a https://iopscience.iop.org/article/10.1088/1361-6498/ac125a https://iopscience.iop.org/article/10.1088/1361-6498/ac125a/pdf |
| Rights: | https://iopscience.iop.org/page/copyright ; https://iopscience.iop.org/info/page/text-and-data-mining |
| رقم الانضمام: | edsbas.DFF90C81 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1088/1361-6498/ac125a |
|---|