Academic Journal
Synthesis and biological activity of Pd(II) and Cu(II) complexes with acylhydrazones of usnic acid
| العنوان: | Synthesis and biological activity of Pd(II) and Cu(II) complexes with acylhydrazones of usnic acid |
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| المؤلفون: | Natić, Maja, Tešić, Živoslav Lj., Anđelković, Katarina K., Brčeski, Ilija, Radulović, Siniša, Manic, S, Sladić, Dušan |
| المصدر: | Synthesis and Reactivity in Inorganic and Metal-organic Chemistry |
| بيانات النشر: | Marcel Dekker Inc, New York |
| سنة النشر: | 2004 |
| المجموعة: | CHERRY - CHEMistry RepositorY, Faculty of Chemistry, University of Belgrade / Repozitorijum Hemijskog fakulteta - Cherry (Univerzitet u Beogradu - Hemijski fakultet) |
| مصطلحات موضوعية: | usnic acid, Pd(II) complex, Cu(II) complex, biological activity, synthesis |
| الوصف: | The complexes of Pd(II) and Cu(II) with the condensation products of usnic acid with hydrazides were prepared and characterized by elemental analyses, IR, H-1 NMR, and C-13 NMR spectroscopy. In all cases, the complexes appear to be monomeric and square-planar, with three binding sites occupied by the dianionic tridentate ligand, and the fourth position occupied by ethanol. The complexes were tested for in vitro growth inhibitory activity against Aspergillus niger, Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis and were found to possess significant activity. The cytotoxic tests were carried out by utilization of the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) microculture colorimetric assay in which human cervix carcinoma HeLa cells were treated by continuous exposure (48 h) to the test agents. All investigated compounds showed cytotoxic activity against HeLa cells with IC50 values between 1.8 and 86.0 muM. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0094-5714 |
| Relation: | https://cherry.chem.bg.ac.rs/handle/123456789/571; 000189254200007; 2-s2.0-1642396487 |
| DOI: | 10.1081/SIM-120027320 |
| الاتاحة: | https://cherry.chem.bg.ac.rs/handle/123456789/571 https://doi.org/10.1081/SIM-120027320 |
| Rights: | restrictedAccess ; ARR |
| رقم الانضمام: | edsbas.DFC99ECC |
| قاعدة البيانات: | BASE |
| تدمد: | 00945714 |
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| DOI: | 10.1081/SIM-120027320 |