Academic Journal
Contribution of birth weight to mental health, cognitive and socioeconomic outcomes: two-sample Mendelian randomisation
| العنوان: | Contribution of birth weight to mental health, cognitive and socioeconomic outcomes: two-sample Mendelian randomisation |
|---|---|
| المؤلفون: | Orri, M, Pingault, J-B, Turecki, G, Nuyt, A-M, Tremblay, RE, Côté, SM, Geoffroy, M-C |
| المصدر: | The British Journal of Psychiatry (2021) (In press). |
| سنة النشر: | 2021 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Mendelian randomisation, Psychiatric disorders, birth weight, intelligence, socioeconomic outcomes |
| الوصف: | BACKGROUND: Low birth weight is associated with adult mental health, cognitive and socioeconomic problems. However, the causal nature of these associations remains difficult to establish owing to confounding. AIMS: To estimate the contribution of birth weight to adult mental health, cognitive and socioeconomic outcomes using two-sample Mendelian randomisation, an instrumental variable approach strengthening causal inference. METHOD: We used 48 independent single-nucleotide polymorphisms as genetic instruments for birth weight (genome-wide association studies' total sample: n = 264 498) and considered mental health (attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder (PTSD), schizophrenia, suicide attempt), cognitive (intelligence) and socioeconomic (educational attainment, income, social deprivation) outcomes. RESULTS: We found evidence for a contribution of birth weight to ADHD (OR for 1 s.d. unit decrease (~464 g) in birth weight, 1.29; 95% CI 1.03-1.62), PTSD (OR = 1.69; 95% CI 1.06-2.71) and suicide attempt (OR = 1.39; 95% CI 1.05-1.84), as well as for intelligence (β = -0.07; 95% CI -0.13 to -0.02) and socioeconomic outcomes, i.e. educational attainment (β = -0.05; 95% CI -0.09 to -0.01), income (β = -0.08; 95% CI -0.15 to -0.02) and social deprivation (β = 0.08; 95% CI 0.03-0.13). However, no evidence was found for a contribution of birth weight to the other examined mental health outcomes. Results were consistent across a wide range of sensitivity analyses. CONCLUSIONS: These findings support the hypothesis that birth weight could be an important element on the causal pathway to mental health, cognitive and socioeconomic outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10122203/3/Orri%20et%20al.%20Birthweight_MR_supplement_BJPsych_acceptedVersion.pdf; https://discovery.ucl.ac.uk/id/eprint/10122203/9/Pingault_Orri%20et%20al.%20Birthweight_MR_BJPsych_acceptedVersion.pdf; https://discovery.ucl.ac.uk/id/eprint/10122203/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10122203/3/Orri%20et%20al.%20Birthweight_MR_supplement_BJPsych_acceptedVersion.pdf https://discovery.ucl.ac.uk/id/eprint/10122203/9/Pingault_Orri%20et%20al.%20Birthweight_MR_BJPsych_acceptedVersion.pdf https://discovery.ucl.ac.uk/id/eprint/10122203/ |
| Rights: | open |
| رقم الانضمام: | edsbas.DFC57A31 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |