التفاصيل البيبلوغرافية
| العنوان: |
In Vitro–In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type |
| المؤلفون: |
Yanping Lin (3639220), David Julian McClements (2624341), Jie Xiao (113647), Yong Cao (9208), Xiaojuan Liu (157559) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Biochemistry, Pharmacology, Biotechnology, Developmental Biology, Science Policy, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, situ intestinal perfusion, mixed micelles formed, larger hydrophobic domains, carrier oils (<, mcts ), long, formulating excipient emulsions, carrier oil type, 9 – 22, 2 – 12, 1 – 13, excipient emulsions, carrier oil, vitro –, oil phase, vivo study, vitro bioaccessibility, results assist, rat serum, pharmacokinetic studies, p < |
| الوصف: |
The influence of the carrier oil type on the bioavailability and bioactivity of flavonoids (quercetin, kaempferol, and apigenin) was examined using in vitro digestion, in situ intestinal perfusion, and pharmacokinetic studies. Here, medium-chain triglycerides (MCTs), long-chain triglycerides (LCTs), or MCT/LCT mixtures (1:1, w/w) served as the oil phase of excipient emulsions. Overall, the bioavailability and antioxidant activity of flavonoids increased when they were coingested with excipient emulsions. The in vitro bioaccessibility of flavonoids was affected by the carrier oil: LCT (17.9–22.8%) > MCT/LCT (12.1–13.7%) > MCT (9.2–12.6%). These differences were mainly attributed to the fact that the mixed micelles formed after the digestion of LCTs had larger hydrophobic domains to solubilize more flavonoids. However, in vivo pharmacokinetic experiments showed that the flavonoid concentrations in rat serum were comparable for all carrier oils ( p > 0.05). Our results assist in formulating excipient emulsions to enhance the efficacy of flavonoids. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/In_Vitro_In_Vivo_Study_of_the_Impact_of_Excipient_Emulsions_on_the_Bioavailability_and_Antioxidant_Activity_of_Flavonoids_Influence_of_the_Carrier_Oil_Type/21790080 |
| DOI: |
10.1021/acs.jafc.2c05836.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.jafc.2c05836.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.DFBFF170 |
| قاعدة البيانات: |
BASE |