Academic Journal
Mechanics of membrane fusion
| العنوان: | Mechanics of membrane fusion |
|---|---|
| المؤلفون: | Leonid V Chernomordik, Michael M Kozlov |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC2548310%26blobtype%3Dpdf. |
| سنة النشر: | 2008 |
| المجموعة: | CiteSeerX |
| الوصف: | Diverse membrane fusion reactions in biology involve close contact between two lipid bilayers, followed by the local distortion of the individual bilayers and reformation into a single, merged membrane. We consider the structures and energies of the fusion intermediates identified in experimental and theoretical work on protein-free lipid bilayers. On the basis of this analysis, we then discuss the conserved fusion-through-hemifusion pathway of merger between biological membranes and propose that the entire progression, from the close juxtaposition of membrane bilayers to the expansion of a fusion pore, is controlled by protein-generated membrane stresses. Cell-to-cell fusion in fertilization, development and carcinogenesis1–3; the membrane-fusion stage of the entry of enveloped viruses4–6; and intracellular fusion reactions in exocytosis, protein trafficking, mitochondrial remodeling and resealing of plasma membranes7–10 are controlled by very different proteins and involve very different membranes (see also Reviews by Wickner and Schekman11, Rizo and Rosenmund12 and Harrison13 in this Special Focus issue). Thus, understanding the molecular mechanisms of specific fusion reactions requires a detailed characterization of the protein structures and |
| نوع الوثيقة: | text |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1027.5961; http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC2548310%26blobtype%3Dpdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1027.5961 http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC2548310%26blobtype%3Dpdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.DFA2FFF3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |