Academic Journal
Levels of plasma brain‐derived tau and p‐tau181 in Alzheimer's disease and rapidly progressive dementias
| العنوان: | Levels of plasma brain‐derived tau and p‐tau181 in Alzheimer's disease and rapidly progressive dementias |
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| المؤلفون: | Gonzalez‐Ortiz, Fernando, Karikari, Thomas K., Bentivenga, Giuseppe Mario, Baiardi, Simone, Mammana, Angela, Turton, Michael, Kac, Przemysław R., Mastrangelo, Andrea, Harrison, Peter, Capellari, Sabina, Zetterberg, Henrik, Blennow, Kaj, Parchi, Piero |
| المساهمون: | Gonzalez‐Ortiz, Fernando, Karikari, Thomas K., Bentivenga, Giuseppe Mario, Baiardi, Simone, Mammana, Angela, Turton, Michael, Kac, Przemysław R., Mastrangelo, Andrea, Harrison, Peter, Capellari, Sabina, Zetterberg, Henrik, Blennow, Kaj, Parchi, Piero |
| سنة النشر: | 2024 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Alzheimer's disease, Creutzfeldt-Jakob disease, blood biomarker, brain-derived tau, rapidly progressive dementia |
| الوصف: | INTRODUCTION: Rapidly progressive dementias (RPDs) are a group of neurological disorders characterized by a rapid cognitive decline. The diagnostic value of blood-based biomarkers for Alzheimer's disease (AD) in RPD has not been fully explored.METHODS: We measured plasma brain-derived tau (BD-tau) and p-tau181 in 11 controls, 15 AD patients, and 33 with RPD, of which 19 were Creutzfeldt-Jakob disease (CJD).RESULTS: Plasma BD-tau differentiated AD from RPD and controls (p = 0.002 and p = 0.03, respectively), while plasma and cerebrospinal fluid (CSF) p-tau181 distinguished AD from RPD (p < 0.001) but not controls from RPD (p > 0.05). The correlation of CSF t-tau with plasma BD-tau was stronger (r = 0.78, p < 0.001) than the correlation of CSF and plasma p-tau181 (r = 0.26, p = 0.04). The ratio BD-tau/p-tau181 performed equivalently to the CSF t-tau/p-tau181 ratio, differentiating AD from CJD (p < 0.0001).DISCUSSION: Plasma BD-tau and p-tau181 mimic their corresponding cerebrospinal fluid (CSF) markers. P-tau significantly increased in AD but not in RPD. Plasma BD-tau, like CSF t-tau, increases according to neurodegeneration intensity. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37858957; volume:20; issue:1; firstpage:745; lastpage:751; numberofpages:7; journal:ALZHEIMER'S & DEMENTIA; https://hdl.handle.net/11585/961158; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85174267712 |
| DOI: | 10.1002/alz.13516 |
| الاتاحة: | https://hdl.handle.net/11585/961158 https://doi.org/10.1002/alz.13516 https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13516 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DF9A79E1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/alz.13516 |
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