التفاصيل البيبلوغرافية
| العنوان: |
Hypocobalamin in a Dog - Hematological Changes ; Hematological changes resulting from hypocobalamin in a dog |
| المؤلفون: |
Saynovich Dutra Silveira, Nathalia, Webber Klasser, Bruno, Karinna Scortegagna Marques, Anna, Machado da Costa, Marcio, Carolina Miotto, Anna, Cristina Blatt Duda, Naila |
| المصدر: |
Acta Scientiae Veterinariae; Vol. 52 (2024): CASE REPORTS (SUPPLEMENT) ; Acta Scientiae Veterinariae; v. 52 (2024): CASE REPORTS (SUPPLEMENT) ; 1679-9216 |
| بيانات النشر: |
Universidade Federal do Rio Grande do Sul |
| سنة النشر: |
2024 |
| المجموعة: |
SEER UFRGS (Universidade Federal do Rio Grande do Sul: Sistema Eletrônico de Editoração de Periódic) |
| مصطلحات موضوعية: |
cabot ring, megaloblastic anemia, vitamina b12 deficiency, hyperfolatemia, siderotic inclusions, myelodysplastic syndrome, vitamin B12 deficiency, iderotic inclusions |
| الوصف: |
Background: Cyanocobalamin is a water-soluble vitamin found mainly in foods of animal origin and is essential for synthesizing proteins, neurotransmitters and nucleic acid. Changes in the metabolism of this vitamin leading to hypocobalaminemia or deficiency are observed in gastrointestinal disorders or hereditary defects resulting in hematological, neurological or metabolic manifestations. This work aims to report the hematological changes resulting from hypocobalaminemia in a canine, diagnosed through the measurement of vitamin B12, folic acid and changes observed in the blood count and myelogram. Case: A 5-year-old castrated male mixed breed dog, weighing 8.30 kg, was treated, with history of main complaint being halitosis and the presence of dental calculus, in addition to difficulty chewing and sporadic vomiting after exercise. In the hematological evaluation, metarubricytosis, the presence of megaloblastic rubrics, leukopenia due to neutropenia, hypersegmented neutrophils and erythrocyte morphological changes were demonstrated in the evaluation of the blood smear, such as macrocytosis with nuclear fragmentation, Cabot rings, basophilic stippling and siderotic inclusions. No changes were found in serum biochemistry, measurement of clotting times, and ultrasound evaluation. The parasitological examination of feces showed cysts of Giardia spp. Vitamin B12 and folic acid were measured, which revealed hypocobalaminemia and hyperfolatemia, and a new blood count and myelogram were subsequently performed, which showed normochromic macrocytic anemia (megaloblastic), erythroid hyperplasia with an increase in precursors and prominent dysplasia (dyserythropoiesis), in addition to mild dysgranulopoiesis and dysmegakaryocytopoiesis, with a suggestive diagnosis of Myelodysplastic Syndrome with Refractory Cytopenia of Multiple Lineages. The main dysplastic changes observed in the erythroid lineage were megaloblastic erythrocytes, multilobulated, nuclear fragmentation, asynchrony in nuclear and cytoplasmic maturation, ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/137306/92395; https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/137306 |
| الاتاحة: |
https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/137306 |
| Rights: |
Copyright (c) 2024 Nathalia Saynovich Dutra Silveira, Bruno Webber Klasser, Anna Karinna Scortegagna Marques, Marcio Machado da Costa, Anna Carolina Miotto, Naila Cristina Blatt Duda ; http://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: |
edsbas.DF778850 |
| قاعدة البيانات: |
BASE |