Academic Journal
Nanoparticles of bioactive glass enhance biodentine bioactivity on dental pulp stem cells
| العنوان: | Nanoparticles of bioactive glass enhance biodentine bioactivity on dental pulp stem cells |
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| المؤلفون: | Corral Núñez, Camila, Altamirano Gaete, Diego, Maureira Vargas, Miguel, Martin Casielles, Javier, Covarrubias Gallardo, Cristián |
| المصدر: | Materials |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Universidad de Chile: Repositorio académico |
| مصطلحات موضوعية: | Apatite-forming ability, Bioactive glass, Bioactivity, Nanocomposites |
| الوصف: | This study aimed to investigate the cytotoxicity and bioactivity of a novel nanocomposite containing nanoparticles of bioactive glass (nBGs) on human dental pulp stem cells (hDPSCs). nBGs were synthesized by the sol-gel method. Biodentine (BD) nanocomposites (nBG/BD) were prepared with 2 and 5% wt of nBG content; unmodified BD and glass ionomer cement were used as references. Cell viability and attachment were evaluated after 3, 7 and 14 days. Odontogenic differentiation was assessed with alkaline phosphatase (ALP) activity after 7 and 14 days of exposure. Cells successfully adhered and proliferated on nBG/BD nanocomposites, cell viability of nanocomposites was comparable with unmodified BD and higher than GIC. nBG/BD nanocomposites were, particularly, more active to promote odontogenic differentiation, expressed as higher ALP activity of hDPSCs after 7 days of exposure, than neat BD or GIC. This novel nanocomposite biomaterial, nBG/BD, allowed hDPSC attachment and proliferation and increased the expression of ALP, upregulated in mineral-producing cells. These findings open opportunities to use nBG/BD in vital pulp therapies. ; Project FONDEQUIP EQM130076 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Materials 2021, 14, 2684.; https://repositorio.uchile.cl/handle/2250/181919 |
| DOI: | 10.3390/ma14102684 |
| الاتاحة: | https://doi.org/10.3390/ma14102684 https://repositorio.uchile.cl/handle/2250/181919 |
| Rights: | Attribution-NonCommercial-NoDerivs 3.0 Chile ; http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ |
| رقم الانضمام: | edsbas.DF536F2E |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ma14102684 |
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