Academic Journal
Targeting BTN2A1 enhances Vγ9Vδ2 T-cell effector functions and triggers tumor cell pyroptosis
| العنوان: | Targeting BTN2A1 enhances Vγ9Vδ2 T-cell effector functions and triggers tumor cell pyroptosis |
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| المؤلفون: | Le Floch, Anne-Charlotte, Imbert, Caroline, Boucherit, Nicolas, Gorvel, Laurent, Fattori, Stéphane, Orlanducci, Florence, Le Roy, Aude, Archetti, Lorenzo, Crescence, Lydie, Panicot-Dubois, Laurence, Dubois, Christophe, Vey, Norbert, Briantais, Antoine, Anastasio, Amandine, Cano, Carla, Guittard, Geoffrey, Frechin, Mathieu, Olive, Daniel |
| المساهمون: | Service d’Hématologie Institut Paoli Calmettes, Marseille, Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Nanolive SA, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital de la Timone CHU - APHM (TIMONE), ImCheck Therapeutics |
| المصدر: | ISSN: 2326-6066 ; Cancer Immunology Research ; https://hal.science/hal-04735873 ; Cancer Immunology Research, In press, ⟨10.1158/2326-6066.CIR-23-0868⟩. |
| بيانات النشر: | HAL CCSD American Association for Cancer Research |
| سنة النشر: | 2024 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology |
| الوصف: | International audience ; Vγ9Vδ2 T cells are potent but elusive cytotoxic effectors. Butyrophilin subfamily 2 member A1 (BTN2A1) is a surface protein that has recently been shown to bind the Vγ9 chain of the γδ T-cell receptor (TCR) but its precise role in modulating Vγ9Vδ2 T-cell functions remains unknown. Here, we show that 107G3B5, a monoclonal BTN2A1 agonist antibody, was able to significantly enhance Vγ9Vδ2 T-cell functions against hematological or solid cell lines and against primary cells from adult acute lymphoblastic leukemia patients. New computer vision strategies applied to holotomographic microscopy videos showed that 107G3B5 enhanced the interaction between Vγ9Vδ2 T cells and target cells in a quantitative and qualitative manner. In addition, we found that Vγ9Vδ2 T cells activated by 107G3B5 induced caspase 3/7 activation in tumor cells, thereby triggering tumor cell death by pyroptosis. Together, these data demonstrate that targeting BTN2A1 with 107G3B5 enhances the Vγ9Vδ2 T-cell antitumor response by triggering the pyroptosis-induced immunogenic cell death. These new pyroptosis-based therapies have great potential to stimulate the immune system to fight cancer, especially “cold” tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1158/2326-6066.CIR-23-0868 |
| الاتاحة: | https://hal.science/hal-04735873 https://hal.science/hal-04735873v1/document https://hal.science/hal-04735873v1/file/315531_2_merged_pdf_10050713_sjrfb4.pdf https://doi.org/10.1158/2326-6066.CIR-23-0868 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.DF436327 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1158/2326-6066.CIR-23-0868 |
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