التفاصيل البيبلوغرافية
| العنوان: |
Probabilities of source aberration with downstream target for breast cancer subtypes. |
| المؤلفون: |
Qian Ke (9164990), Wikum Dinalankara (10526113), Laurent Younes (10960956), Donald Geman (78677), Luigi Marchionni (363972) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Genetics, Molecular Biology, Cancer, Infectious Diseases, Computational Biology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, heterogeneity, dysregulated gene expression programs, configuration, TCGA, tumor, type, source gene, sample, DNA-RNA aberrations Cancer cells di., profile, STP |
| الوصف: |
For PAM50 subtypes of breast cancer, the heatmap represents the probabilities that the indicated gene is a DNA-aberrant source gene with some downstream RNA-aberrant target. The sources are selected from the set of core genes for coverings of the given tissue; the selection criterion is that the probability of a DNA-aberration is high for at least one of the subtypes for that tissue. Core sources with varying probabilities present interesting candidates for discrimination between subtypes. For example, the DNA-aberration frequency of TP53 is much higher in the HER2-enriched and Basal-like subtypes than in Luminal A and Luminal B, whereas an aberration in PIK3CA is less frequent among basal-like samples than among the other subtypes. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Probabilities_of_source_aberration_with_downstream_target_for_breast_cancer_subtypes_/14772717 |
| DOI: |
10.1371/journal.pcbi.1008944.t006 |
| الاتاحة: |
https://doi.org/10.1371/journal.pcbi.1008944.t006 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.DF433011 |
| قاعدة البيانات: |
BASE |