Academic Journal
Analysis of skin dose distribution for the prediction of severe radiation dermatitis in head and neck squamous cell carcinoma patients treated with concurrent chemo‐radiotherapy
| العنوان: | Analysis of skin dose distribution for the prediction of severe radiation dermatitis in head and neck squamous cell carcinoma patients treated with concurrent chemo‐radiotherapy |
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| المؤلفون: | Bonomo, Pierluigi, Talamonti, Cinzia, Desideri, Isacco, Marrazzo, Livia, Pezzulla, Donato, Rampini, Andrea, Bertocci, Silvia, De Majo, Roberta, Gasperi, Chiara, Curion, Assunta Simona, Lastrucci, Luciana, Dominici, Luca, Pallotta, Stefania, Livi, Lorenzo, Caini, Saverio |
| المصدر: | Head & Neck ; volume 42, issue 2, page 244-253 ; ISSN 1043-3074 1097-0347 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background We investigated whether the pattern of intensity‐modulated radiotherapy (IMRT) dose distribution to the skin can be correlated with the development of G3/G4 radiation dermatitis (RD). Methods A frequency‐matched cohort analysis was perfomed on patients treated with IMRT and concurrent cisplatin or cetuximab. Risk ratios were obtained by fitting Poisson regression models. Results The incidence of G3/G4 RD was 41.1% in 90 patients included (50% vs 36.6% in the cetuximab and cisplatin cohorts, respectively). In multivariate analysis, PS ≥ 1 and weight loss at RT completion >10 kg were the only factors that retained significance. The best dosimetric predictive accuracy was provided by 19.9 cc and 5.8 cc of skin ring 2 mm V50 and V60, respectively (AUC: 0.61 for both). Conclusion Along with clinical factors, the pattern of dose distribution to a ring structure localized 2 mm below the patient's surface may help predict the development of severe RD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/hed.25997 |
| الاتاحة: | http://dx.doi.org/10.1002/hed.25997 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhed.25997 https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.25997 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/hed.25997 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.DF3F3989 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/hed.25997 |
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